| Literature DB >> 19939465 |
Alessandra Aldinucci1, Tiziana Biagioli, Cinzia Manuelli, Anna Maria Repice, Luca Massacesi, Clara Ballerini.
Abstract
Azathioprine (Aza), 6-Mercaptopurine (6-MP) and 6-Thioguanine (6-TG) are thiopurine drugs widely used as immunosuppressants/anti-inflammatory agents in organ transplantation and chemotherapy. Aza is well tolerated and effective in modifying the course of MS. Here we investigated the action of 6-MP on human dendritic cells (DCs). We described for the first time that 6-MP impairs in vitro differentiation of DCs, has an inhibitory effect during DC activation processes inducing a functionally less immunogenic phenotype. Moreover, 6-MP significantly reduces DC IL-23 production and CCR7 expression, at the same time induces IL-10 augmentation. All these findings add a novel action mechanism in Aza immune modulation. Copyright 2009 Elsevier B.V. All rights reserved.Entities:
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Year: 2009 PMID： 19939465 DOI： 10.1016/j.jneuroim.2009.11.001
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478