OBJECTIVE: To ascertain meiotic aneuploidy of the human egg using array comparative genomic hybridization to evaluate the 23-paired chromosome copy number of first polar body as an objective prognosticator of embryo viability for embryo transfer in the same cycle. DESIGN: Case report. SETTING: Independent-sector IVF program. PATIENT(S): A 41-year-old woman with a history of 13 failed cycles of IVF. INTERVENTION(S): Polar body biopsy of metaphase II eggs. MAIN OUTCOME MEASURE(S): Birth. RESULT(S): Two of the nine eggs were euploid, and the resulting embryos, although morphologically inferior to sibling embryos, were selected for transfer to the uterus, resulting in the birth of a normal healthy baby. CONCLUSION(S): Selection of euploid eggs, as an objective parameter of subsequent embryo viability and with the opportunity to transfer embryos in the same cycle could maximise the opportunity for live birth after IVF even in cases with poor prognosis. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
OBJECTIVE: To ascertain meiotic aneuploidy of the human egg using array comparative genomic hybridization to evaluate the 23-paired chromosome copy number of first polar body as an objective prognosticator of embryo viability for embryo transfer in the same cycle. DESIGN: Case report. SETTING: Independent-sector IVF program. PATIENT(S): A 41-year-old woman with a history of 13 failed cycles of IVF. INTERVENTION(S): Polar body biopsy of metaphase II eggs. MAIN OUTCOME MEASURE(S): Birth. RESULT(S): Two of the nine eggs were euploid, and the resulting embryos, although morphologically inferior to sibling embryos, were selected for transfer to the uterus, resulting in the birth of a normal healthy baby. CONCLUSION(S): Selection of euploid eggs, as an objective parameter of subsequent embryo viability and with the opportunity to transfer embryos in the same cycle could maximise the opportunity for live birth after IVF even in cases with poor prognosis. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Authors: D Ioannou; K G L Fonseka; E J Meershoek; A R Thornhill; A Abogrein; M Ellis; D K Griffin Journal: Chromosome Res Date: 2012-06-29 Impact factor: 5.239
Authors: Martin D Keltz; Mario Vega; Ido Sirota; Matthew Lederman; Erin L Moshier; Eric Gonzales; Daniel Stein Journal: J Assist Reprod Genet Date: 2013-08-16 Impact factor: 3.412
Authors: Alem S Gabriel; Terry J Hassold; Alan R Thornhill; Nabeel A Affara; Alan H Handyside; Darren K Griffin Journal: Chromosome Res Date: 2011-01-12 Impact factor: 5.239
Authors: L Gianaroli; M C Magli; G Cavallini; A Crippa; A Capoti; S Resta; F Robles; A P Ferraretti Journal: Hum Reprod Date: 2010-07-08 Impact factor: 6.918
Authors: Zhihong Yang; Jiaen Liu; Gary S Collins; Shala A Salem; Xiaohong Liu; Sarah S Lyle; Alison C Peck; E Scott Sills; Rifaat D Salem Journal: Mol Cytogenet Date: 2012-05-02 Impact factor: 2.009
Authors: Joep Geraedts; Markus Montag; M Cristina Magli; Sjoerd Repping; Alan Handyside; Catherine Staessen; Joyce Harper; Andreas Schmutzler; John Collins; Veerle Goossens; Hans van der Ven; Katerina Vesela; Luca Gianaroli Journal: Hum Reprod Date: 2011-09-09 Impact factor: 6.918