| Literature DB >> 19938842 |
Laura H Riihimäki-Lampén1, Mikko J Vainio, Mikko Vahermo, Leena L Pohjala, Jonna M S Heikura, Kaija H Valkonen, Vesa T Virtanen, Jari T Yli-Kauhaluoma, Pia M Vuorela.
Abstract
The binding of therapeutically relevant synthetic retinoid derivatives to bovine and reindeer beta-lactoglobulin (betaLG) is demonstrated using fluorescence quenching and ultrafiltration/HPLC methods. Furthermore, synthesis of methyl (E)-3-[4-[(E)-2-(2,6,6-trimethylcyclohex-1-enyl)vinyl]phenyl]-acrylate 4 and (E)-3-[4-[(E)-2-(2,6,6-trimethylcyclohex-1-enyl)vinyl]phenyl]acrylic acid 5 is described. All studied compounds bind to both betaLG homologues with nanomolar K(d) values, and the interaction diminishes the pH-dependent aggregation of retinoids. Thus, betaLG may show benefits in improving the bioavailability of retinoid derivatives.Entities:
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Year: 2010 PMID： 19938842 DOI： 10.1021/jm901309r
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446