Literature DB >> 19937499

Association of FcRn Heavy Chain Encoding Gene (FCGRT) Polymorphisms with IgG Content in Bovine Colostrum.

Ran Zhang1, Zhihui Zhao, Yaofeng Zhao, Imre Kacskovics, Marjolein van der Eijk, Nanda de Groot, Ning Li, Lennart Hammarstrom.   

Abstract

In this study, we evaluated haplotypes of the bovine FCGRT (encoding the FcRn heavy chain) and their relationship to the IgG concentration in bovine colostrum. Four single nucleotide polymorphism (SNP), classified into five haplotypes, were identified in a total of 49 Holstein-Frisians cows. Haplotype 5 was found to be significantly associated with a high IgG level ([OR] = 9.90, 95%CI = 1.11-88.34, p = 0.016) and haplotype 2 exhibited a similar trend ([OR] = 2.89, 95%CI = 1.17-7.11, p = 0.019).

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Year:  2009        PMID: 19937499     DOI: 10.1080/10495390903196448

Source DB:  PubMed          Journal:  Anim Biotechnol        ISSN: 1049-5398            Impact factor:   2.282


  6 in total

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