| Literature DB >> 19937092 |
Dagang Guo1, J Jillian Zhang, Xin-Yun Huang.
Abstract
Guanosine 3',5'-cyclic monophosphate (cGMP) and small GTPase Rac are critical regulators of cell functions. Recently, Rac has been shown to use its downstream effector p21-activated kinase (PAK) to directly activate transmembrane guanylyl cyclases (GCs). This novel Rac/PAK/GC/cGMP signaling pathway bridges Rac and cGMP, and provides a general molecular mechanism for diverse receptors to regulate physiological functions such as cell migration through elevating the cellular cGMP level.Entities:
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Year: 2009 PMID： 19937092 PMCID： PMC2832591 DOI： 10.1007/s11010-009-0327-7
Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396