Literature DB >> 19935274

Emergence of drug resistance in HIV-1 subtype C infected children failing the South African national antiretroviral roll-out program.

Carole L Wallis1, Linda Erasmus, Sheba Varughese, Dalu Ndiweni, Wendy S Stevens.   

Abstract

HIV-1 drug resistance patterns in 41 children failing antiretroviral therapy in South Africa were examined. Resistance mutation profiles were similar to adults published from the region, with the exception of high rates of lopinavir/r resistance (44%). Ninety-eight percent presented with known drug resistance mutations with M184V (82%) and K103N (44%), the dominant mutations.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19935274     DOI： 10.1097/INF.0b013e3181af5a00

Source DB:  PubMed          Journal:  Pediatr Infect Dis J        ISSN： 0891-3668            Impact factor:   2.129


  9 in total

1.  Drug resistance and coreceptor usage in HIV type 1 subtype C-infected children initiating or failing highly active antiretroviral therapy in South Africa.

Authors:  Taryn N Green; Mohendran Archary; Michelle L Gordon; Nagavelli Padayachi; Yolanda Lie; Elizabeth D Anton; Jacqueline D Reeves; Anneke Grobler; Raziya Bobat; Hoosen Coovadia; Thumbi Ndung'u
Journal:  AIDS Res Hum Retroviruses       Date:  2011-08-05       Impact factor: 2.205

2.  Rapid development of antiretroviral drug resistance mutations in HIV-infected children less than two years of age initiating protease inhibitor-based therapy in South Africa.

Authors:  Barbara S Taylor; Gillian Hunt; Elaine J Abrams; Ashraf Coovadia; Tammy Meyers; Gayle Sherman; Renate Strehlau; Lynn Morris; Louise Kuhn
Journal:  AIDS Res Hum Retroviruses       Date:  2011-03-23       Impact factor: 2.205

3.  Effects of the W153L substitution in HIV reverse transcriptase on viral replication and drug resistance to multiple categories of reverse transcriptase inhibitors.

Authors:  Hong-Tao Xu; Susan P Colby-Germinario; Maureen Oliveira; Daniel Rajotte; Richard Bethell; Mark A Wainberg
Journal:  Antimicrob Agents Chemother       Date:  2014-05-27       Impact factor: 5.191

4.  Resistance in pediatric patients experiencing virologic failure with first-line and second-line antiretroviral therapy.

Authors:  Catherine Orrell; Julie Levison; Andrea Ciaranello; Linda-Gail Bekker; Daniel R Kuritzkes; Kenneth A Freedberg; Robin Wood
Journal:  Pediatr Infect Dis J       Date:  2013-06       Impact factor: 2.129

5.  Factors Associated with the Development of Drug Resistance Mutations in HIV-1 Infected Children Failing Protease Inhibitor-Based Antiretroviral Therapy in South Africa.

Authors:  Theresa M Rossouw; Ute D Feucht; George Melikian; Gisela van Dyk; Winifred Thomas; Nicolette M du Plessis; Theunis Avenant
Journal:  PLoS One       Date:  2015-07-21       Impact factor: 3.240

6.  Drug resistance in children at virological failure in a rural KwaZulu-Natal, South Africa, cohort.

Authors:  Sureshnee Pillay; Ruth M Bland; Richard J Lessells; Justen Manasa; Tulio de Oliveira; Sivapragashini Danaviah
Journal:  AIDS Res Ther       Date:  2014-01-20       Impact factor: 2.250

7.  High levels of virological failure with major genotypic resistance mutations in HIV-1-infected children after 5 years of care according to WHO-recommended 1st-line and 2nd-line antiretroviral regimens in the Central African Republic: A cross-sectional study.

Authors:  Christian Diamant Mossoro-Kpinde; Jean-Chrysostome Gody; Ralph-Sydney Mboumba Bouassa; Olivia Mbitikon; Mohammad-Ali Jenabian; Leman Robin; Mathieu Matta; Kamal Zeitouni; Jean De Dieu Longo; Cecilia Costiniuk; Gérard Grésenguet; Ndèye Coumba Touré Kane; Laurent Bélec
Journal:  Medicine (Baltimore)       Date:  2017-03       Impact factor: 1.889

8.  High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen.

Authors:  Kim Steegen; Leon Levin; Irene Ketseoglou; Michelle Bronze; Maria A Papathanasopoulos; Sergio Carmona; Wendy Stevens
Journal:  PLoS One       Date:  2014-05-09       Impact factor: 3.240

9.  HIV type 1 drug resistance patterns among patients failing first and second line antiretroviral therapy in Nairobi, Kenya.

Authors:  Peter Koigi; Musa Otieno Ngayo; Samoel Khamadi; Caroline Ngugi; Anthony Kebira Nyamache
Journal:  BMC Res Notes       Date:  2014-12-09
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.