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Literature DB >> 1993464

Trypanosoma cruzi: shedding of surface antigens as membrane vesicles.

M F Gonçalves¹, E S Umezawa, A M Katzin, W de Souza, M J Alves, B Zingales, W Colli.

Abstract

Tissue culture-derived trypomastigotes from Trypanosoma cruzi spontaneously shed surface antigens into the culture medium. The shedding is a temperature- and time-dependent phenomenon and is independent of the presence of proteins or immune serum in the medium. The analysis of this process in four strains (Y, YuYu, CA1, and RA) showed differences in the amounts of polypeptides released. However, for all strains the liberation of the entire set of surface polypeptides ranging in molecular mass from 70 to 150 kDa was observed. Biochemical and electron microscopic data strongly suggest that most of the surface antigens are released as plasma membrane vesicles, ranging from 20 to 80 nm in diameter.

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Year: 1991 PMID： 1993464 DOI： 10.1016/0014-4894(91)90119-h

Source DB: PubMed Journal: Exp Parasitol ISSN： 0014-4894 Impact factor: 2.011

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Cited

57 in total

Review 1. Exosomes or microvesicles? Two kinds of extracellular vesicles with different routes to modify protozoan-host cell interaction.

Authors: Ingrid Evans-Osses; Luis H Reichembach; Marcel I Ramirez
Journal: Parasitol Res Date: 2015-08-15 Impact factor: 2.289

2. Biological properties of extracellular vesicles and their physiological functions.

Authors: María Yáñez-Mó; Pia R-M Siljander; Zoraida Andreu; Apolonija Bedina Zavec; Francesc E Borràs; Edit I Buzas; Krisztina Buzas; Enriqueta Casal; Francesco Cappello; Joana Carvalho; Eva Colás; Anabela Cordeiro-da Silva; Stefano Fais; Juan M Falcon-Perez; Irene M Ghobrial; Bernd Giebel; Mario Gimona; Michael Graner; Ihsan Gursel; Mayda Gursel; Niels H H Heegaard; An Hendrix; Peter Kierulf; Katsutoshi Kokubun; Maja Kosanovic; Veronika Kralj-Iglic; Eva-Maria Krämer-Albers; Saara Laitinen; Cecilia Lässer; Thomas Lener; Erzsébet Ligeti; Aija Linē; Georg Lipps; Alicia Llorente; Jan Lötvall; Mateja Manček-Keber; Antonio Marcilla; Maria Mittelbrunn; Irina Nazarenko; Esther N M Nolte-'t Hoen; Tuula A Nyman; Lorraine O'Driscoll; Mireia Olivan; Carla Oliveira; Éva Pállinger; Hernando A Del Portillo; Jaume Reventós; Marina Rigau; Eva Rohde; Marei Sammar; Francisco Sánchez-Madrid; N Santarém; Katharina Schallmoser; Marie Stampe Ostenfeld; Willem Stoorvogel; Roman Stukelj; Susanne G Van der Grein; M Helena Vasconcelos; Marca H M Wauben; Olivier De Wever
Journal: J Extracell Vesicles Date: 2015-05-14

Review 3. Message in a vesicle - trans-kingdom intercommunication at the vector-host interface.

Authors: Adela S Oliva Chávez; Anya J O'Neal; Laura Santambrogio; Michail Kotsyfakis; Joao H F Pedra
Journal: J Cell Sci Date: 2019-03-18 Impact factor: 5.285

Review 4. The role of extracellular vesicles in Plasmodium and other protozoan parasites.

Authors: Pierre-Yves Mantel; Matthias Marti
Journal: Cell Microbiol Date: 2014-03 Impact factor: 3.715

5. Characterization and Diagnostic Application of Trypanosoma cruzi Trypomastigote Excreted-Secreted Antigens Shed in Extracellular Vesicles Released from Infected Mammalian Cells.

Authors: Norma L Bautista-López; Momar Ndao; Fabio Vasquez Camargo; Takeshi Nara; Takeshi Annoura; Darryl B Hardie; Christoph H Borchers; Armando Jardim
Journal: J Clin Microbiol Date: 2016-12-14 Impact factor: 5.948

10. Further characterization of protective Trypanosoma cruzi-specific CD4+ T-cell clones: T helper type 1-like phenotype and reactivity with shed trypomastigote antigens.

Authors: S P Nickell; M Keane; M So
Journal: Infect Immun Date: 1993-08 Impact factor: 3.441

Trypanosoma cruzi: shedding of surface antigens as membrane vesicles.

Review 1. Exosomes or microvesicles? Two kinds of extracellular vesicles with different routes to modify protozoan-host cell interaction.

2. Biological properties of extracellular vesicles and their physiological functions.

Review 3. Message in a vesicle - trans-kingdom intercommunication at the vector-host interface.

Review 4. The role of extracellular vesicles in Plasmodium and other protozoan parasites.

5. Characterization and Diagnostic Application of Trypanosoma cruzi Trypomastigote Excreted-Secreted Antigens Shed in Extracellular Vesicles Released from Infected Mammalian Cells.

Review 6. Sending a message: extracellular vesicles of pathogenic protozoan parasites.

7. Modulation of host cell mechanics by Trypanosoma cruzi.

8. A new cruzipain-mediated pathway of human cell invasion by Trypanosoma cruzi requires trypomastigote membranes.

9. Detection and characterization of antigens in urine of patients with acute, congenital, and chronic Chagas' disease.

10. Further characterization of protective Trypanosoma cruzi-specific CD4+ T-cell clones: T helper type 1-like phenotype and reactivity with shed trypomastigote antigens.