Literature DB >> 19934603

TP53 Polymorphisms allow for genetic sub-grouping of the canine transmissible venereal tumor.

Abel Sánchez-Servín1, Simón Martínez, Emilio Córdova-Alarcon, Raúl Fajardo.   

Abstract

The canine transmissible venereal tumor (CTVT) is found mainly in dogs' sexual organs. Currently, it is widely accepted that all samples of CTVT show similar histopathological characteristics and share common genetic alterations. Despite the common genetic origin of CTVT, mutations in the P53 gene have been reported. In this study, we proposed that tumor samples can be genetically grouped using this gene. The presence of different subgroups of CTVT was determined in Mexican dogs using the TP53 gene sequence in CTVT samples. Four new polymorphisms were found and therefore, the CTVT samples were classified in five subgroups.

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Year:  2009        PMID： 19934603      PMCID： PMC2807274          DOI： 10.4142/jvs.2009.10.4.353

Source DB:  PubMed          Journal:  J Vet Sci        ISSN： 1229-845X            Impact factor:   1.672


  10 in total

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Authors:  M Oren
Journal:  J Biol Chem       Date:  1999-12-17       Impact factor: 5.157

2.  Aberrations of the p53 tumor suppressor gene in various tumors in dogs.

Authors:  A Setoguchi; T Sakai; M Okuda; K Minehata; M Yazawa; T Ishizaka; T Watari; R Nishimura; N Sasaki; A Hasegawa; H Tsujimoto
Journal:  Am J Vet Res       Date:  2001-03       Impact factor: 1.156

3.  Sequence analysis of canine LINE-1 elements and p53 gene in canine transmissible venereal tumor.

Authors:  Young-Ki Choi; Chul-Joong Kim
Journal:  J Vet Sci       Date:  2002-12       Impact factor: 1.672

4.  Metastatic transmissible venereal tumour in dogs.

Authors:  O O Oduye; B O Ikede; G O Esuruoso; J U Akpokodje
Journal:  J Small Anim Pract       Date:  1973-10       Impact factor: 1.522

5.  Vincristine for treatment of transmissible venereal tumor in the dog--.

Authors:  C A Calvert; C E Leifer; E G MacEwen
Journal:  J Am Vet Med Assoc       Date:  1982-07-15       Impact factor: 1.936

6.  Isolation of canine p53 cDNA and detailed characterization of the full length canine p53 protein.

Authors:  N Veldhoen; J Milner
Journal:  Oncogene       Date:  1998-02-26       Impact factor: 9.867

7.  Origins and evolution of a transmissible cancer.

Authors:  Clare A Rebbeck; Rachael Thomas; Matthew Breen; Armand M Leroi; Austin Burt
Journal:  Evolution       Date:  2009-04-30       Impact factor: 3.694

8.  The T963C mutation of TP53 gene does not participate in the clonal origin of canine TVT.

Authors:  N Vázquez-Mota; J Simón-Martínez; E Córdova-Alarcon; L Lagunes; R Fajardo
Journal:  Vet Res Commun       Date:  2007-08-01       Impact factor: 2.459

9.  Identification of canine transmissible venereal tumor cells using in situ polymerase chain reaction and the stable sequence of the long interspersed nuclear element.

Authors:  Kuang-Wen Liao; Zei-Yi Lin; Hai-Nie Pao; Sook-Yee Kam; Fun-In Wang; Rea-Min Chu
Journal:  J Vet Diagn Invest       Date:  2003-09       Impact factor: 1.279

10.  Clonal origin and evolution of a transmissible cancer.

Authors:  Claudio Murgia; Jonathan K Pritchard; Su Yeon Kim; Ariberto Fassati; Robin A Weiss
Journal:  Cell       Date:  2006-08-11       Impact factor: 41.582
  10 in total
  1 in total

1.  Impact of the K24N mutation on the transactivation domain of p53 and its binding to murine double-minute clone 2.

Authors:  Yingqian Ada Zhan; Hongwei Wu; Anne T Powell; Gary W Daughdrill; F Marty Ytreberg
Journal:  Proteins       Date:  2013-07-22
  1 in total

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