Literature DB >> 19933800

In vivo assessment of the antimicrobial activity of a calcium-deficient apatite vancomycin drug delivery system in a methicillin-resistant Staphylococcus aureus rabbit osteomyelitis experimental model.

G Amador1, H Gautier, V Le Mabecque, A F Miegeville, G Potel, J-M Bouler, P Weiss, J Caillon, C Jacqueline.   

Abstract

The antimicrobial activities of calcium-deficient apatite loaded with different concentrations (25, 100, and 500 microg/mg) of vancomycin as a filling biomaterial were evaluated in a methicillin-resistant Staphylococcus aureus (MRSA) rabbit acute osteomyelitis model. Bacterial counts in bone, bone marrow, and joint fluid samples treated with forms of the apatite were compared to those in tissue samples receiving a constant intravenous vancomycin infusion after 4 days. This study demonstrates that using a calcium-deficient apatite loaded with vancomycin dramatically decreases the bacterial counts in bone and marrow.

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Year:  2009        PMID： 19933800      PMCID： PMC2812125          DOI： 10.1128/AAC.00434-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  Osteomyelitis.

Authors: 
Journal:  Curr Infect Dis Rep       Date:  1999-08       Impact factor: 3.725

2.  Calcium-deficient apatite: a first in vivo study concerning bone ingrowth.

Authors:  B Bourgeois; O Laboux; L Obadia; O Gauthier; E Betti; E Aguado; G Daculsi; J-M Bouler
Journal:  J Biomed Mater Res A       Date:  2003-06-01       Impact factor: 4.396

Review 3.  Diagnosis and management of methicillin resistant Staphylococcus aureus infection.

Authors:  G J Duckworth
Journal:  BMJ       Date:  1993-10-23

Review 4.  Osteomyelitis: the past decade.

Authors:  F A Waldvogel; P S Papageorgiou
Journal:  N Engl J Med       Date:  1980-08-14       Impact factor: 91.245

5.  Continuous versus intermittent infusion of vancomycin in severe Staphylococcal infections: prospective multicenter randomized study.

Authors:  M Wysocki; F Delatour; F Faurisson; A Rauss; Y Pean; B Misset; F Thomas; J F Timsit; T Similowski; H Mentec; L Mier; D Dreyfuss
Journal:  Antimicrob Agents Chemother       Date:  2001-09       Impact factor: 5.191

6.  Comparative evaluation of tigecycline and vancomycin, with and without rifampicin, in the treatment of methicillin-resistant Staphylococcus aureus experimental osteomyelitis in a rabbit model.

Authors:  Li-Yan Yin; Luca Lazzarini; Fan Li; C Melinda Stevens; Jason H Calhoun
Journal:  J Antimicrob Chemother       Date:  2005-04-27       Impact factor: 5.790

Review 7.  Antibiotic treatment of gram-positive bone and joint infections.

Authors:  Elizabeth S R Darley; Alasdair P MacGowan
Journal:  J Antimicrob Chemother       Date:  2004-04-29       Impact factor: 5.790

8.  Comparative severity of pediatric osteomyelitis attributable to methicillin-resistant versus methicillin-sensitive Staphylococcus aureus.

Authors:  John J Hawkshead; Nimesh B Patel; Russell W Steele; Stephen D Heinrich
Journal:  J Pediatr Orthop       Date:  2009 Jan-Feb       Impact factor: 2.324

Review 9.  Local antibacterial therapy for the management of orthopaedic infections. Pharmacokinetic considerations.

Authors:  S L Henry; K P Galloway
Journal:  Clin Pharmacokinet       Date:  1995-07       Impact factor: 6.447

10.  Calcium-deficient apatite: influence of granule size and consolidation mode on release and in vitro activity of vancomycin.

Authors:  L Obadia; G Amador; G Daculsi; J-M Bouler
Journal:  Biomaterials       Date:  2003-03       Impact factor: 12.479
  10 in total
  3 in total

Review 1.  Biomaterials approaches to treating implant-associated osteomyelitis.

Authors:  Jason A Inzana; Edward M Schwarz; Stephen L Kates; Hani A Awad
Journal:  Biomaterials       Date:  2015-12-18       Impact factor: 12.479

2.  Animal experimental investigation on the efficacy of antibiotic therapy with linezolid, vancomycin, cotrimoxazole, and rifampin in treatment of periprosthetic knee joint infections by MRSA.

Authors:  Julia Goetz; Verena Keyssner; Frank Hanses; Felix Greimel; Franziska Leiß; Timo Schwarz; Hans-Robert Springorum; Joachim Grifka; Jens Schaumburger
Journal:  Bone Joint Res       Date:  2022-03       Impact factor: 5.853

3.  The Antistaphylococcal Activity of Amoxicillin/Clavulanic Acid, Gentamicin, and 1,8-Cineole Alone or in Combination and Their Efficacy through a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Osteomyelitis.

Authors:  Soukayna Hriouech; Ahmed A Akhmouch; Aouatef Mzabi; Hanane Chefchaou; Mariam Tanghort; Bouchra Oumokhtar; Najat Chami; Adnane Remmal
Journal:  Evid Based Complement Alternat Med       Date:  2020-04-28       Impact factor: 2.629
  3 in total

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