| Literature DB >> 19932972 |
William J Moore1, Jeffrey C Kern, Ramesh Bhat, Peter V N Bodine, Shoichi Fukyama, Girija Krishnamurthy, Ronald L Magolda, Keith Pitts, Barb Stauffer, Eugene J Trybulski.
Abstract
Piperidinyl diphenylsulfonyl sulfonamides are a novel class of molecules that have inhibitory binding affinity for sFRP-1. As a secreted protein sFRP-1 inhibits the function of the secreted Wnt glycoprotein. Therefore, as inhibitors of sFRP-1 these small molecules facilitate the Wnt/beta-catenin canonical signaling pathway. Details of the structure-activity relationships and biological activity of this structural class of compounds will be discussed. Copyright (c) 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 19932972 DOI： 10.1016/j.bmc.2009.11.002
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641