OBJECTIVE: To evaluate the effect of hyperandrogenism on metabolic disorders among patients with polycystic ovary syndrome (PCOS) diagnosed using the Rotterdam criteria. METHODS: A retrospective analysis of the clinical records of 883 women with PCOS and 717 premenopausal controls identified from the general population. RESULTS: A total of 686 (77.7%) patients were classified with PCOS based on National Institutes of Health (NIH) criteria, and 164 out of 197 (83.2%) additional patients had no hyperandrogenism. Women with normal androgen levels exhibited lower frequencies of obesity, type 2 diabetes, acanthosis nigricans, genetic history of diabetes, and elevated Matsuda index compared with hyperandrogenic patients. Hyperandrogenemia, but not hirsutism, was independently associated with the risk for type 2 diabetes (odds ratio [OR] 5.7; P=0.028) and obesity (OR 1.7; P=0.005) among Chinese patients with PCOS. CONCLUSIONS: Hyperandrogenemia is associated with type 2 diabetes and obesity in Chinese women with PCOS and should be considered at first-line management of hyperandrogenism and infertility due to PCOS. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
OBJECTIVE: To evaluate the effect of hyperandrogenism on metabolic disorders among patients with polycystic ovary syndrome (PCOS) diagnosed using the Rotterdam criteria. METHODS: A retrospective analysis of the clinical records of 883 women with PCOS and 717 premenopausal controls identified from the general population. RESULTS: A total of 686 (77.7%) patients were classified with PCOS based on National Institutes of Health (NIH) criteria, and 164 out of 197 (83.2%) additional patients had no hyperandrogenism. Women with normal androgen levels exhibited lower frequencies of obesity, type 2 diabetes, acanthosis nigricans, genetic history of diabetes, and elevated Matsuda index compared with hyperandrogenicpatients. Hyperandrogenemia, but not hirsutism, was independently associated with the risk for type 2 diabetes (odds ratio [OR] 5.7; P=0.028) and obesity (OR 1.7; P=0.005) among Chinese patients with PCOS. CONCLUSIONS:Hyperandrogenemia is associated with type 2 diabetes and obesity in Chinese women with PCOS and should be considered at first-line management of hyperandrogenism and infertility due to PCOS. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
Authors: M M Ollila; S West; S Keinänen-Kiukaanniemi; J Jokelainen; J Auvinen; K Puukka; A Ruokonen; M-R Järvelin; J S Tapanainen; S Franks; T T Piltonen; L C Morin-Papunen Journal: Hum Reprod Date: 2016-12-28 Impact factor: 6.918