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Literature DB >> 19932616

Structure-based design, synthesis and biological evaluation of new N-carboxyphenylpyrrole derivatives as HIV fusion inhibitors targeting gp41.

Yong Wang¹, Hong Lu, Qiang Zhu, Shibo Jiang, Yun Liao.

Abstract

A new series of N-carboxyphenylpyrrole ligands were designed using GeometryFit based on an X-ray crystal structure of gp41. The synthesized ligands showed significant inhibitory activities against HIV gp41 6-helix bundle formation, HIV-1 mediated cell-cell fusion and HIV-1 replication. Copyright 2009 Elsevier Ltd. All rights reserved.

Entities: Chemical Disease Gene Species

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Year: 2009 PMID： 19932616 PMCID： PMC2818531 DOI： 10.1016/j.bmcl.2009.10.139

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

31 in total

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12 in total

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6. Identification and characterization of inhibitors of the aminoglycoside resistance acetyltransferase Eis from Mycobacterium tuberculosis.

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