Literature DB >> 19932529

Synthesis, DNA-binding, photocleavage, cytotoxicity and antioxidant activity of ruthenium (II) polypyridyl complexes.

Yun-Jun Liu1, Cheng-Hui Zeng, Hong-Liang Huang, Li-Xin He, Fu-Hai Wu.   

Abstract

Two new ligands maip (1a), paip (1b) with their ruthenium (II) complexes [Ru(bpy)(2)(maip)](ClO(4))(2) (2a) and [Ru(bpy)(2)(paip)](ClO(4))(2) (2b) have been synthesized and characterized. The results show that complexes 2a and 2b interact with DNA through intercalative mode. The cytotoxicity of these compounds has been evaluated by MTT assay. The experiments on antioxidant activity show that these compounds exhibit good antioxidant activity against hydroxyl radical (OH). Crown Copyright 2009. Published by Elsevier Masson SAS. All rights reserved.

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Year:  2009        PMID： 19932529     DOI： 10.1016/j.ejmech.2009.10.043

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  7 in total

1.  DNA binding, antitumor activities, and hydroxyl radical scavenging properties of novel oxovanadium (IV) complexes with substituted isoniazid.

Authors:  Xiangwen Liao; Jiazheng Lu; Peng Ying; Ping Zhao; Yinliang Bai; Wengjie Li; Mingpei Liu
Journal:  J Biol Inorg Chem       Date:  2013-12       Impact factor: 3.358

2.  Synthesis and characterization of mixed-ligand diimine-piperonal thiosemicarbazone complexes of ruthenium(II): Biophysical investigations and biological evaluation as anticancer and antibacterial agents.

Authors:  Floyd A Beckford; Jeffrey Thessing; Michael Shaloski; P Canisius Mbarushimana; Alyssa Brock; Jacob Didion; Jason Woods; Antonio Gonzalez-Sarrías; Navindra P Seeram
Journal:  J Mol Struct       Date:  2011-04-19       Impact factor: 3.196

3.  Binding properties of Ru(II) polypyridyl complexes with poly(U)·poly(A)*poly(U) triplex: the ancillary ligand effect on third-strand stabilization.

Authors:  Li-Feng Tan; Ling-Jun Xie; Xiao-Nan Sun
Journal:  J Biol Inorg Chem       Date:  2012-10-31       Impact factor: 3.358

4.  Synthesis, characterization, and DNA binding, photocleavage, cytotoxicity, cellular uptake, apoptosis, and on-off light switching studies of Ru(II) mixed-ligand complexes containing 7-fluorodipyrido[3,2-a:2',3'-c]phenazine.

Authors:  Nancherla Deepika; Yata Praveen Kumar; Chittimalli Shobha Devi; Putta Venkat Reddy; Avudoddi Srishailam; Sirasani Satyanarayana
Journal:  J Biol Inorg Chem       Date:  2013-07-12       Impact factor: 3.358

5.  Molecular aspects on the interaction of isatin-3-isonicotinylhydrazone to deoxyribonucleic acid: model for intercalative drug-DNA binding.

Authors:  Soheila Kashanian; Mohammad Mehdi Khodaei; Parvaneh Pakravan; Hadi Adibi
Journal:  Mol Biol Rep       Date:  2011-07-21       Impact factor: 2.742

6.  SYNTHESIS AND EVALUATION OF WATER-SOLUBLE DIMETHYLAMINOETHYL ETHERS OF METHOXSALEN FOR PROLIFERATIVE SKIN DISORDERS.

Authors:  Christophe D Guillon; Yi-Hua Jan; Natalie Foster; Mridula Choudhuri; Jaya Saxena; Thomas M Mariano; Diane E Heck; Jeffrey D Laskin; Ned D Heindel
Journal:  Heterocycl Lett       Date:  2018 Aug-Oct

7.  Study on nucleic acid (CT-DNA and yeast tRNA) binding behaviors and cytotoxic properties of a heterodinuclear Ru(II)-Co(III) polypyridyl complex.

Authors:  Xiling Liang; Xiaoqing Zou; Lifeng Tan; Weiguo Zhu
Journal:  J Inorg Biochem       Date:  2010-08-18       Impact factor: 4.155
  7 in total

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