OBJECTIVE: To investigate whether the systemic inflammation induced by chlamydial infections might be associated with symptoms of polycystic ovary syndrome (PCOS). DESIGN: Nested case-control study. SETTING: A questionnaire including questions about hirsutism and oligo-amenorrhea was distributed to a representative sample of women (at age 31) from the general population-based Northern Finland Birth Cohort. Those who reported both symptoms were defined as symptomatic (n=81). PATIENT(S): A representative sample of women (at age 31) from the general population-based Northern Finland Birth Cohort. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): To test the presence of serum antibodies to Chlamydia pneumoniae (IgG titers ≥32) and Chlamydia trachomatis (IgG titers ≥8) by microimmunofluorescence in symptomatic and control women. RESULT(S): Antibodies were investigated in 79 symptomatic and 1427 control women (C. pneumoniae) and in 79 symptomatic and 425 control women (C trachomatis). C. trachomatis antibodies (odds ratio [OR], 2.4; 95% confidence interval [CI], 1.3-4.6) and C. pneumoniae antibodies (OR, 1.5; 95% CI, 1.0-2.4) were more commonly present in symptomatic women, and the simultaneous presence of elevated highly sensitive C-reactive protein levels strengthened this association. CONCLUSION(S): Chronic inflammation, which is associated with chlamydial infections, could contribute to the pathogenetic processes that lead to the metabolic and hormonal disorders of PCOS.
OBJECTIVE: To investigate whether the systemic inflammation induced by chlamydial infections might be associated with symptoms of polycystic ovary syndrome (PCOS). DESIGN: Nested case-control study. SETTING: A questionnaire including questions about hirsutism and oligo-amenorrhea was distributed to a representative sample of women (at age 31) from the general population-based Northern Finland Birth Cohort. Those who reported both symptoms were defined as symptomatic (n=81). PATIENT(S): A representative sample of women (at age 31) from the general population-based Northern Finland Birth Cohort. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): To test the presence of serum antibodies to Chlamydia pneumoniae (IgG titers ≥32) and Chlamydia trachomatis (IgG titers ≥8) by microimmunofluorescence in symptomatic and control women. RESULT(S): Antibodies were investigated in 79 symptomatic and 1427 control women (C. pneumoniae) and in 79 symptomatic and 425 control women (C trachomatis). C. trachomatis antibodies (odds ratio [OR], 2.4; 95% confidence interval [CI], 1.3-4.6) and C. pneumoniae antibodies (OR, 1.5; 95% CI, 1.0-2.4) were more commonly present in symptomatic women, and the simultaneous presence of elevated highly sensitive C-reactive protein levels strengthened this association. CONCLUSION(S): Chronic inflammation, which is associated with chlamydial infections, could contribute to the pathogenetic processes that lead to the metabolic and hormonal disorders of PCOS.
Authors: Renato Pasquali; Elisabet Stener-Victorin; Bulent O Yildiz; Antoni J Duleba; Kathleen Hoeger; Helen Mason; Roy Homburg; Theresa Hickey; Steve Franks; Juha S Tapanainen; Adam Balen; David H Abbott; Evanthia Diamanti-Kandarakis; Richard S Legro Journal: Clin Endocrinol (Oxf) Date: 2011-04 Impact factor: 3.478
Authors: Chelsea W Fox; Lingzhi Zhang; Abhishek Sohni; Manuel Doblado; Miles F Wilkinson; R Jeffrey Chang; Antoni J Duleba Journal: Endocrinology Date: 2019-12-01 Impact factor: 4.736
Authors: Tee Cian Yeow; Won Fen Wong; Negar Shafiei Sabet; Sofiah Sulaiman; Fatemeh Shahhosseini; Grace Min Yi Tan; Elaheh Movahed; Chung Yeng Looi; Esaki M Shankar; Rishien Gupta; Bernard P Arulanandam; Jamiyah Hassan; Sazaly Abu Bakar Journal: BMC Microbiol Date: 2016-03-18 Impact factor: 3.605