Literature DB >> 1993038

Effects of antiflammins on endotoxin-induced uveitis in rats.

C C Chan1, M Ni, L Miele, E Cordella-Miele, M Ferrick, A B Mukherjee, R B Nussenblatt.   

Abstract

Antiflammins are phospholipase A2-inhibitory, anti-inflammatory, synthetic oligopeptides derived from the region of the highest amino-acid sequence similarity between uteroglobin and lipocortin I. Endotoxin-induced uveitis is a model for anterior uveitis of the eye, which has been suggested to be induced through phospholipase A2 activation. In a preliminary report we demonstrated that topical administration of antiflammins could inhibit endotoxin-induced uveitis in rats. In this study, the anti-inflammatory effects of antiflammins were compared with those of corticosteroids on endotoxin-induced uveitis as measured by phospholipase A2 enzyme activity, inflammatory cell counts in the aqueous humor, and histopathologic features. Antiflammins are as effective as corticosteroids in their ability to suppress endotoxin-induced uveitis.

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Year:  1991        PMID： 1993038     DOI： 10.1001/archopht.1991.01080020124058

Source DB:  PubMed          Journal:  Arch Ophthalmol        ISSN： 0003-9950


  8 in total

1.  Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature.

Authors:  Vincenzo Brancaleone; Jesmond Dalli; Stefania Bena; Roderick J Flower; Giuseppe Cirino; Mauro Perretti
Journal:  J Immunol       Date:  2011-03-11       Impact factor: 5.422

2.  Oxidative degradation of antiflammin 2.

Authors:  J M Ye; J L Wolfe
Journal:  Pharm Res       Date:  1996-02       Impact factor: 4.200

3.  Resonance assignment and secondary structure determination and stability of the recombinant human uteroglobin with heteronuclear multidimensional NMR.

Authors:  T Carlomagno; G Mantile; R Bazzo; L Miele; L Paolillo; A B Mukherjee; G Barbato
Journal:  J Biomol NMR       Date:  1997-01       Impact factor: 2.835

4.  Tissue-specific expression of the gene coding for human Clara cell 10-kD protein, a phospholipase A2-inhibitory protein.

Authors:  A Peri; E Cordella-Miele; L Miele; A B Mukherjee
Journal:  J Clin Invest       Date:  1993-11       Impact factor: 14.808

5.  Inhibition of intraocular fibrin formation with annexin V.

Authors:  P Chollet; F Malecaze; F Hullin; P Raynal; J L Arne; V Pagot; J Ragab-Thomas; H Chap
Journal:  Br J Ophthalmol       Date:  1992-08       Impact factor: 4.638

Review 6.  Uteroglobin and uteroglobin-like proteins: the uteroglobin family of proteins.

Authors:  L Miele; E Cordella-Miele; G Mantile; A Peri; A B Mukherjee
Journal:  J Endocrinol Invest       Date:  1994-09       Impact factor: 4.256

7.  Inhibition of smooth muscle contraction and platelet aggregation by peptide 204-212 of lipocortin 5: an attempt to define some structure requirements.

Authors:  K G Mugridge; C Becherucci; L Parente; M Perretti
Journal:  Mediators Inflamm       Date:  1993       Impact factor: 4.711

8.  Antiflammin-1 attenuates bleomycin-induced pulmonary fibrosis in mice.

Authors:  Wei Liu; Jing Wan; Jian-Zhong Han; Chen Li; Dan-Dan Feng; Shao-Jie Yue; Yan-Hong Huang; Yi Chen; Qing-Mei Cheng; Yang Li; Zi-Qiang Luo
Journal:  Respir Res       Date:  2013-10-08
  8 in total

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