BACKGROUND: Red blood cell (RBC) use varies greatly between countries but the underlying reasons are not well understood. Some insight might be gained from blood utilization studies that provide a complete view of the clinical conditions that place individuals at risk of transfusion. This review considers the methodology of published studies that might provide such information and proposes requirements for future studies. STUDY DESIGN AND METHODS: A literature search was performed to identify quantitative studies of RBC use related to clinical data, for which the findings are representative of well-defined populations. Extraction and analysis of methodologic information and epidemiologic data were performed. RESULTS: The 13 studies identified for inclusion varied in their approach to defining the population from which the study sample was selected, classification of clinical data, and method of attributing transfusion events to clinical case groups, including the observational time frame. CONCLUSION: Variability in methods prevents useful interpretation or comparison of the findings. Standardization and transparency of methodology and definitions are essential if future studies are to enable comparison of the factors associated with RBC transfusion in different populations and to improve understanding of the wide variations in RBC use.
BACKGROUND: Red blood cell (RBC) use varies greatly between countries but the underlying reasons are not well understood. Some insight might be gained from blood utilization studies that provide a complete view of the clinical conditions that place individuals at risk of transfusion. This review considers the methodology of published studies that might provide such information and proposes requirements for future studies. STUDY DESIGN AND METHODS: A literature search was performed to identify quantitative studies of RBC use related to clinical data, for which the findings are representative of well-defined populations. Extraction and analysis of methodologic information and epidemiologic data were performed. RESULTS: The 13 studies identified for inclusion varied in their approach to defining the population from which the study sample was selected, classification of clinical data, and method of attributing transfusion events to clinical case groups, including the observational time frame. CONCLUSION: Variability in methods prevents useful interpretation or comparison of the findings. Standardization and transparency of methodology and definitions are essential if future studies are to enable comparison of the factors associated with RBC transfusion in different populations and to improve understanding of the wide variations in RBC use.
Authors: Nyashadzaishe Mafirakureva; Star Khoza; Oliver Hassall; Brian E Faragher; Isaac Kajja; David A Mvere; Jean C Emmanuel; Maarten J Postma; Marinus van Hulst Journal: Blood Transfus Date: 2015-07-15 Impact factor: 3.443
Authors: R Georg Geißler; Dominik Franz; Hubert Buddendick; Petra Krakowitzky; Holger Bunzemeier; Norbert Roeder; Hugo Van Aken; Torsten Kessler; Wolfgang Berdel; Walter Sibrowski; Peter Schlenke Journal: Transfus Med Hemother Date: 2012-03-22 Impact factor: 3.747
Authors: Loan R van Hoeven; Babette H Hooftman; Mart P Janssen; Martine C de Bruijne; Karen M K de Vooght; Peter Kemper; Maria M W Koopman Journal: BMJ Open Date: 2016-08-04 Impact factor: 2.692
Authors: Loan R van Hoeven; Aukje L Kreuger; Kit Cb Roes; Peter F Kemper; Hendrik Koffijberg; Floris J Kranenburg; Jan Mm Rondeel; Mart P Janssen Journal: Clin Epidemiol Date: 2018-03-29 Impact factor: 4.790