Literature DB >> 19929808

The complexes of drugs with carbohydrate-containing plant metabolites as pharmacologically promising agents.

T G Tolstikova1, M V Khvostov, A O Bryzgalov.   

Abstract

Complexation of known drugs with carbohydrate-containing plant metabolites is a promising way to synthesize new drugs that does not only save pharmacological properties of initial agent but also acquire a number of advantageous features such as increased water solubility, bioavailability and decreased toxicity. This review reports on the development and pharmacological evaluation of novel complexes of various well-known drugs with vegetable coplexation agents: glycyrrhizic acid, Stevia glycosides, gypsogenin tetraoside, pectin, xyloglucan, arabinogalactan. The aim of this review is to describe advantages of the new approach, suggested by authors, in the development of low toxic and high-performance drugs.

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Year:  2009        PMID: 19929808     DOI: 10.2174/138955709789878123

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN: 1389-5575            Impact factor:   3.862


  11 in total

1.  Supramolecular Complex of Ibuprofen with Larch Polysaccharide Arabinogalactan: Studies on Bioavailability and Pharmacokinetics.

Authors:  Mikhail V Khvostov; Sergey A Borisov; Tatjana G Tolstikova; Alexander V Dushkin; Biligma D Tsyrenova; Yulia S Chistyachenko; Nikolay E Polyakov; Galina G Dultseva; Andrey A Onischuk; Sergey V An'kov
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2017-06       Impact factor: 2.441

2.  Topical Glycyrrhizin Is Therapeutic for Pseudomonas aeruginosa Keratitis.

Authors:  Sandamali A Ekanayaka; Sharon A McClellan; Ronald P Barrett; Linda D Hazlett
Journal:  J Ocul Pharmacol Ther       Date:  2017-12-13       Impact factor: 2.671

3.  Effect of complexation with arabinogalactan on pharmacokinetics of "guest" drugs in rats: for example, warfarin.

Authors:  Mikhail V Khvostov; Alexander A Chernonosov; Tatjana G Tolstikova; Marat F Kasakin; Olga S Fedorova; Alexander V Dushkin
Journal:  Biomed Res Int       Date:  2013-12-26       Impact factor: 3.411

Review 4.  Supramolecular Carotenoid Complexes of Enhanced Solubility and Stability-The Way of Bioavailability Improvement.

Authors:  A Ligia Focsan; Nikolay E Polyakov; Lowell D Kispert
Journal:  Molecules       Date:  2019-10-31       Impact factor: 4.411

Review 5.  Glycyrrhizic acid as a multifunctional drug carrier - From physicochemical properties to biomedical applications: A modern insight on the ancient drug.

Authors:  O Yu Selyutina; N E Polyakov
Journal:  Int J Pharm       Date:  2019-01-25       Impact factor: 5.875

6.  pH-Sensitive Glycyrrhizin Based Vesicles for Nifedipine Delivery.

Authors:  Olga Yu Selyutina; Anna V Mastova; Ekaterina A Shelepova; Nikolay E Polyakov
Journal:  Molecules       Date:  2021-02-26       Impact factor: 4.411

7.  Effect of glycyrrhizic acid on phospholipid membranes in media with different pH.

Authors:  O Yu Selyutina; P A Kononova; N E Polyakov
Journal:  Russ Chem Bull       Date:  2022-01-26       Impact factor: 1.704

8.  Mechanism of the enhancing effect of glycyrrhizin on nifedipine penetration through a lipid membrane.

Authors:  A V Kim; E A Shelepova; V I Evseenko; A V Dushkin; N N Medvedev; N E Polyakov
Journal:  J Mol Liq       Date:  2021-10-09       Impact factor: 6.165

9.  Exploring the therapeutic mechanisms of Cassia glauca in diabetes mellitus through network pharmacology, molecular docking and molecular dynamics.

Authors:  Prarambh S R Dwivedi; Rajesh Patil; Pukar Khanal; Nilambari S Gurav; Vaishali D Murade; Dinesh P Hase; Mohan G Kalaskar; Muniappan Ayyanar; Rupesh V Chikhale; Shailendra S Gurav
Journal:  RSC Adv       Date:  2021-12-09       Impact factor: 4.036

10.  Inhibitory effects and actions of pentacyclic triterpenes upon glycation.

Authors:  Mei-Chin Yin
Journal:  Biomedicine (Taipei)       Date:  2015-08-11
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