BACKGROUND: Recent literature suggests a role for apolipoprotein L (apoL) aberrations in the pathogenesis of schizophrenia. ApoL is almost exclusively associated with apolipoprotein A-I in high-density lipoproteins (HDLs). The objective of this study was to examine the correlation between symptom scores and serum HDL in antipsychotic-naive schizophrenia patients. METHODS: In this cross-sectional study, 60 antipsychotic-naive schizophrenia patients were systematically examined for their symptom scores, with good inter-rater reliability. Concurrently, an overnight fasting serum lipid profile from these patients was assessed. RESULTS: Serum HDL had a significant inverse correlation with a total negative syndrome score (rho=-0.43; p=0.001). CONCLUSIONS: The study observation supports the potential role for HDL abnormalities in the genesis of negative symptoms in schizophrenia.
BACKGROUND: Recent literature suggests a role for apolipoprotein L (apoL) aberrations in the pathogenesis of schizophrenia. ApoL is almost exclusively associated with apolipoprotein A-I in high-density lipoproteins (HDLs). The objective of this study was to examine the correlation between symptom scores and serum HDL in antipsychotic-naive schizophreniapatients. METHODS: In this cross-sectional study, 60 antipsychotic-naive schizophreniapatients were systematically examined for their symptom scores, with good inter-rater reliability. Concurrently, an overnight fasting serum lipid profile from these patients was assessed. RESULTS: Serum HDL had a significant inverse correlation with a total negative syndrome score (rho=-0.43; p=0.001). CONCLUSIONS: The study observation supports the potential role for HDL abnormalities in the genesis of negative symptoms in schizophrenia.
Authors: Anastasiia S Boiko; Irina A Mednova; Elena G Kornetova; Arkadiy V Semke; Nikolay A Bokhan; Anton J M Loonen; Svetlana A Ivanova Journal: Heliyon Date: 2019-07-03