OBJECTIVE: Chronic or acute rejection is a leading cause of allograft loss after solid organ transplantation and the presence of memory T cells is associated with increased propensity for allograft rejection. The purpose of this study was to investigate the correlation between immunophenotypic shift of memory CD8+ T cells and immune status in the patients after liver transplantation. MATERIAL AND METHODS: Seventy-three blood samples were collected and varied compartments of memory CD8+ T cells were analysed in non-rejected and rejected patients. RESULTS: The results show that with time elapsed, the immunophenotypes of memory CD8+ cells shifted from naive T cells to central or intermediate memory cells, and then to effector or terminal memory cells in non-rejected patients. This course was correlated with the expression of CD127 on CD8+ T cells. In rejected patients, the main proportion of CD8+ cells were dominated by naive CD8+ cells and then rapidly restored to the immunophenotypes of memory T cells after effective treatment. CONCLUSION: These results demonstrated that immunophenotypic shift of memory CD8+ T cells was closely related to the change of the immune status in the patients after liver transplantation. Monitoring the immunophenotypic shift of memory CD8+ T cells is of great importance in the prediction for allograft rejection and treatment effectiveness after liver transplantation.
OBJECTIVE: Chronic or acute rejection is a leading cause of allograft loss after solid organ transplantation and the presence of memory T cells is associated with increased propensity for allograft rejection. The purpose of this study was to investigate the correlation between immunophenotypic shift of memory CD8+ T cells and immune status in the patients after liver transplantation. MATERIAL AND METHODS: Seventy-three blood samples were collected and varied compartments of memory CD8+ T cells were analysed in non-rejected and rejected patients. RESULTS: The results show that with time elapsed, the immunophenotypes of memory CD8+ cells shifted from naive T cells to central or intermediate memory cells, and then to effector or terminal memory cells in non-rejected patients. This course was correlated with the expression of CD127 on CD8+ T cells. In rejected patients, the main proportion of CD8+ cells were dominated by naive CD8+ cells and then rapidly restored to the immunophenotypes of memory T cells after effective treatment. CONCLUSION: These results demonstrated that immunophenotypic shift of memory CD8+ T cells was closely related to the change of the immune status in the patients after liver transplantation. Monitoring the immunophenotypic shift of memory CD8+ T cells is of great importance in the prediction for allograft rejection and treatment effectiveness after liver transplantation.
Authors: William Bracamonte-Baran; Nisha A Gilotra; Taejoon Won; Katrina M Rodriguez; Monica V Talor; Byoung C Oh; Jan Griffin; Ilan Wittstein; Kavita Sharma; John Skinner; Roger A Johns; Stuart D Russell; Robert A Anders; Qingfeng Zhu; Marc K Halushka; Gerald Brandacher; Daniela Čiháková Journal: Circ Heart Fail Date: 2021-09-24 Impact factor: 10.447
Authors: David San Segundo; María Ángeles Ballesteros; Sara Naranjo; Felipe Zurbano; Eduardo Miñambres; Marcos López-Hoyos Journal: PLoS One Date: 2013-11-13 Impact factor: 3.240
Authors: David S Segundo; Gema Fernández-Fresnedo; María Gago; Iñaki Beares; Marta González; Juan C Ruiz; Manuel Arias; Marcos López-Hoyos Journal: Kidney Int Suppl (2011) Date: 2011-08