Alfonso Fasano1, Anna Rita Bentivoglio. 1. Università Cattolica del Sacro Cuore, Istituto di Neurologia, Largo Agostino Gemelli, 8-00168 Roma, Italy. alfonso.fasano@rm.unicatt.it
Abstract
BACKGROUND: Tetrabenazine (TBZ) depletes presynaptic dopamine in the CNS. It has been found to be beneficial in hyperkinetic movement disorders without carrying the extrapyramidal side effects that are characteristic of neuroleptics. OBJECTIVE: To summarize current knowledge on the use of TBZ and draw conclusions about its efficacy and safety. METHODS: PubMed literature searches using the term 'tetrabenazine' were carried out for the period prior to May 2009. Additional relevant studies referenced by these publications were included. CONCLUSIONS: Both short- and long-term studies have consistently yielded favorable results for the use of TBZ in the treatment of hyperkinetic movement in terms of efficacy and safety. TBZ is most effective in reducing chorea (including Huntington's disease associated chorea), tic associated with Tourette's syndrome and tardive dyskinesias. Furthermore, TBZ might also have potential for use in other hyperkinetic disorders (e.g., myoclonus and dystonia), for which future clinical trials are needed.
BACKGROUND:Tetrabenazine (TBZ) depletes presynaptic dopamine in the CNS. It has been found to be beneficial in hyperkinetic movement disorders without carrying the extrapyramidal side effects that are characteristic of neuroleptics. OBJECTIVE: To summarize current knowledge on the use of TBZ and draw conclusions about its efficacy and safety. METHODS: PubMed literature searches using the term 'tetrabenazine' were carried out for the period prior to May 2009. Additional relevant studies referenced by these publications were included. CONCLUSIONS: Both short- and long-term studies have consistently yielded favorable results for the use of TBZ in the treatment of hyperkinetic movement in terms of efficacy and safety. TBZ is most effective in reducing chorea (including Huntington's disease associated chorea), tic associated with Tourette's syndrome and tardive dyskinesias. Furthermore, TBZ might also have potential for use in other hyperkinetic disorders (e.g., myoclonus and dystonia), for which future clinical trials are needed.
Authors: Marta Pardo; Laura López-Cruz; Noemí San Miguel; John D Salamone; Mercè Correa Journal: Psychopharmacology (Berl) Date: 2015-02-03 Impact factor: 4.530
Authors: Qian-Sheng Yu; Weiming Luo; Jeffery Deschamps; Harold W Holloway; Theresa Kopajtic; Jonathan L Katz; Arnold Brossi; Nigel H Greig Journal: ACS Med Chem Lett Date: 2010-03-31 Impact factor: 4.345
Authors: Wardell E Amerika; Saskia van der Gaag; Arne Mosch; Niels A van der Gaag; Carel F E Hoffmann; Rodi Zutt; Johan Marinus; Maria Fiorella Contarino Journal: Mov Disord Clin Pract Date: 2022-05-24