Literature DB >> 19928961

Unnatural amino acid substitution as a probe of the allosteric coupling pathway in a mycobacterial Cu(I) sensor.

Zhen Ma1, Darin M Cowart, Brian P Ward, Randy J Arnold, Richard D DiMarchi, Limei Zhang, Graham N George, Robert A Scott, David P Giedroc.   

Abstract

The Cu(I) sensor Mycobacterium tuberculosis CsoR is a founding member of a new metalloregulatory protein family. Here we show that two "atom" substitutions of the Nepsilon2 face of a Cu(I) coordinating histidine-61 allosterically uncouple Cu(I) and DNA binding, with no effect on Cu(I) binding affinity and coordination structure. A model analogous to the allosteric switch mechanism in Staphylococcus aureus CzrA, a zinc sensor protein with a completely different fold, is proposed.

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Year:  2009        PMID： 19928961      PMCID： PMC2797707          DOI： 10.1021/ja908372b

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  16 in total

1.  Evolutionarily conserved networks of residues mediate allosteric communication in proteins.

Authors:  Gürol M Süel; Steve W Lockless; Mark A Wall; Rama Ranganathan
Journal:  Nat Struct Biol       Date:  2003-01

Review 2.  The role of dynamics in allosteric regulation.

Authors:  Dorothee Kern; Erik R P Zuiderweg
Journal:  Curr Opin Struct Biol       Date:  2003-12       Impact factor: 6.809

Review 3.  Allosteric regulation and catalysis emerge via a common route.

Authors:  Nina M Goodey; Stephen J Benkovic
Journal:  Nat Chem Biol       Date:  2008-08       Impact factor: 15.040

Review 4.  The origin of protein interactions and allostery in colocalization.

Authors:  John Kuriyan; David Eisenberg
Journal:  Nature       Date:  2007-12-13       Impact factor: 49.962

5.  Solution structure of a paradigm ArsR family zinc sensor in the DNA-bound state.

Authors:  Alphonse I Arunkumar; Gregory C Campanello; David P Giedroc
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-12       Impact factor: 11.205

6.  CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator.

Authors:  Tong Liu; Arati Ramesh; Zhen Ma; Sarah K Ward; Limei Zhang; Graham N George; Adel M Talaat; James C Sacchettini; David P Giedroc
Journal:  Nat Chem Biol       Date:  2006-12-03       Impact factor: 15.040

7.  Individual metal ligands play distinct functional roles in the zinc sensor Staphylococcus aureus CzrA.

Authors:  Mario A Pennella; Alphonse I Arunkumar; David P Giedroc
Journal:  J Mol Biol       Date:  2005-12-22       Impact factor: 5.469

8.  Transfer of copper between bis(thiosemicarbazone) ligands and intracellular copper-binding proteins. insights into mechanisms of copper uptake and hypoxia selectivity.

Authors:  Zhiguang Xiao; Paul S Donnelly; Matthias Zimmermann; Anthony G Wedd
Journal:  Inorg Chem       Date:  2008-04-16       Impact factor: 5.165

9.  Ni(II) and Co(II) sensing by Escherichia coli RcnR.

Authors:  Jeffrey S Iwig; Sharon Leitch; Robert W Herbst; Michael J Maroney; Peter T Chivers
Journal:  J Am Chem Soc       Date:  2008-05-28       Impact factor: 15.419

Review 10.  Metal sensor proteins: nature's metalloregulated allosteric switches.

Authors:  David P Giedroc; Alphonse I Arunkumar
Journal:  Dalton Trans       Date:  2007-06-28       Impact factor: 4.390
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  32 in total

Review 1.  Metalloregulatory proteins: metal selectivity and allosteric switching.

Authors:  Hermes Reyes-Caballero; Gregory C Campanello; David P Giedroc
Journal:  Biophys Chem       Date:  2011-04-05       Impact factor: 2.352

2.  Ratiometric pulse-chase amidination mass spectrometry as a probe of biomolecular complex formation.

Authors:  Feng-Ming James Chang; Matthew A Lauber; William E Running; James P Reilly; David P Giedroc
Journal:  Anal Chem       Date:  2011-10-31       Impact factor: 6.986

3.  Role of the N-terminus in determining metal-specific responses in the E. coli Ni- and Co-responsive metalloregulator, RcnR.

Authors:  Khadine A Higgins; Peter T Chivers; Michael J Maroney
Journal:  J Am Chem Soc       Date:  2012-04-11       Impact factor: 15.419

4.  The interplay of the metallosensor CueR with two distinct CopZ chaperones defines copper homeostasis in Pseudomonas aeruginosa.

Authors:  Lorena Novoa-Aponte; David Ramírez; José M Argüello
Journal:  J Biol Chem       Date:  2019-02-04       Impact factor: 5.157

5.  The CsoR-like sulfurtransferase repressor (CstR) is a persulfide sensor in Staphylococcus aureus.

Authors:  Justin L Luebke; Jiangchuan Shen; Kevin E Bruce; Thomas E Kehl-Fie; Hui Peng; Eric P Skaar; David P Giedroc
Journal:  Mol Microbiol       Date:  2014-11-17       Impact factor: 3.501

6.  Glutamate Ligation in the Ni(II)- and Co(II)-Responsive Escherichia coli Transcriptional Regulator, RcnR.

Authors:  Carolyn E Carr; Francesco Musiani; Hsin-Ting Huang; Peter T Chivers; Stefano Ciurli; Michael J Maroney
Journal:  Inorg Chem       Date:  2017-05-18       Impact factor: 5.165

7.  Selenite and tellurite form mixed seleno- and tellurotrisulfides with CstR from Staphylococcus aureus.

Authors:  Justin L Luebke; Randy J Arnold; David P Giedroc
Journal:  Metallomics       Date:  2013-04       Impact factor: 4.526

8.  Allosteric inhibition of a zinc-sensing transcriptional repressor: insights into the arsenic repressor (ArsR) family.

Authors:  Gregory C Campanello; Zhen Ma; Nicholas E Grossoehme; Alfredo J Guerra; Brian P Ward; Richard D Dimarchi; Yuzhen Ye; Charles E Dann; David P Giedroc
Journal:  J Mol Biol       Date:  2013-01-23       Impact factor: 5.469

9.  Effects of select histidine to cysteine mutations on transcriptional regulation by Escherichia coli RcnR.

Authors:  Khadine A Higgins; Heidi Q Hu; Peter T Chivers; Michael J Maroney
Journal:  Biochemistry       Date:  2012-12-24       Impact factor: 3.162

10.  Energetics of zinc-mediated interactions in the allosteric pathways of metal sensor proteins.

Authors:  Dhruva K Chakravorty; Trent M Parker; Alfredo J Guerra; C David Sherrill; David P Giedroc; Kenneth M Merz
Journal:  J Am Chem Soc       Date:  2012-12-26       Impact factor: 15.419
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