Literature DB >> 19928912

Novel syntheses of tetrahydrobenzodiazepines and dihydropyrazines via isocyanide-based multicomponent reactions of diamines.

Ahmad Shaabani1, Ali Maleki, Fatemeh Hajishaabanha, Hamid Mofakham, Mozhdeh Seyyedhamzeh, Mojtaba Mahyari, Seik Weng Ng.   

Abstract

In this work, two novel isocyanide-based multicomponent reactions of 1,2-diamine compounds with diketene have been developed as efficient strategies for the synthesis of 2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-2-carboxamides with regiochemical control and 1,6-dihydropyrazine-2,3-dicarbonitriles in good to excellent yields at ambient temperature.

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Year:  2010        PMID: 19928912     DOI: 10.1021/cc900125a

Source DB:  PubMed          Journal:  J Comb Chem        ISSN: 1520-4766


  4 in total

1.  A novel one-pot pseudo-five-component condensation reaction towards bifunctional diazepine-tetrazole containing compounds: synthesis of 1H-tetrazolyl-1H-1,4-diazepine-2,3-dicarbonitriles and 1H-tetrazolyl-benzo[b][1,4]diazepines.

Authors:  Hamid Mofakham; Ahmad Shaabani; Sajjad Mousavifaraz; Fatemeh Hajishaabanha; Shabnam Shaabani; Seik Weng Ng
Journal:  Mol Divers       Date:  2012-05-17       Impact factor: 2.943

2.  Ammonium chloride-catalyzed green multicomponent synthesis of dihydropyrazine and tetrahydrodiazepine derivatives "on water".

Authors:  Ahmad Shaabani; Heshmatollah Sepahvand; Shima Ghasemi
Journal:  Mol Divers       Date:  2018-11-21       Impact factor: 2.943

Review 3.  Use of multicomponent reactions in developing small-molecule tools to study GABAA receptor mechanism and function.

Authors:  Ryan W Lewis; George P Hess; Bruce Ganem
Journal:  Future Med Chem       Date:  2011-02       Impact factor: 3.808

4.  Recent Advances in the Development of Catalytic Methods that Construct Medium-ring Lactams, Partially Saturated Benzazepines and their Derivatives.

Authors:  Wrickban Mazumdar; Tom G Driver
Journal:  Synthesis (Stuttg)       Date:  2021       Impact factor: 3.157

  4 in total

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