| Literature DB >> 19928811 |
Su Yu1, Anthony Haight, Brian Kotecki, Lei Wang, Kirill Lukin, David R Hill.
Abstract
A five-step synthesis of a TRPV1 receptor antagonist 1 is described. The key step involves a novel palladium-catalyzed amidation reaction of 4-chloro-1-methylindazole 8 with the benzyl urea 9 to form the unsymmetrically substituted urea 1.Entities:
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Year: 2009 PMID： 19928811 DOI： 10.1021/jo901943s
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354