| Literature DB >> 19928780 |
Chada Raji Reddy1, Gajula Dharmapuri, Nagavaram Narsimha Rao.
Abstract
The asymmetric synthesis of the fully functionalized macrocyclic core of iriomoteolide 3a, a cytotoxic 15-membered macrolide, is disclosed. The key steps involve Sharpless asymmetric dihydroxylation, Sharpless asymmetric epoxidation, olefin cross-metathesis, Yamaguchi esterification, and a ring-closing metathesis reaction for macrocyclization.Entities:
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Year: 2009 PMID： 19928780 DOI： 10.1021/ol9025183
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005