| Literature DB >> 19928353 |
Shirin Bahmanyar1, W James Nelson, Angela I M Barth.
Abstract
Adenomatous polyposis coli (APC) is a multifunctional protein commonly mutated in colon cancer. APC contains binding sites for multiple proteins with diverse roles in signaling and the structural and functional organization of cells. Recent evidence suggests roles for APC and some of its binding partners in regulating microtubules in mitosis. APC localizes to three key locations in mitosis: kinetochores, the cortex and centrosomes. Here, we discuss possible mechanisms for APC function at these sites and suggest new pathways by which APC mutations promote tumorigenesis.Entities:
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Year: 2009 PMID： 19928353 PMCID： PMC3373726 DOI： 10.1007/978-1-4419-1145-2_6
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622