Nonbacterial prostatitis in Kunming mouse induced by long-term stimuli of passive sexual abstinence.

In this study, a state of sexual abstinence was imitated in Kunming male mice. Further assessment on the body and prostate weight and histomorphometric changes of the prostate showed that nonbacterial prostatitis in Kunming mice could be induced by long-term stimuli of passive sexual abstinence, and the normal physiological state of the mice could be kept in the process of induction. The analysis of the result suggests that copulation might be a protective factor in the process of nonbacterial prostatitis. The underlying mechanisms of this model may include immune response on prostate antigen, chronic pelvic congestion, disturbance of hormone regulation, and other mechanisms; this requires confirmation by further research.