| Literature DB >> 19926524 |
Feng Feng1, Jennifer Nyland, Michelle Banyai, Arthur Tatum, Allen E Silverstone, Jerrie Gavalchin.
Abstract
In order to investigate the roles of ER subtypes in the estrogen-induced lupus phenotype, ERalpha-deficient (ERalpha(-/-)) and wild-type mice (WT) were injected monthly with estradiol (E-2) starting at 8 weeks. In WT mice, E-2 treatment induced a lupus phenotype, with accelerated death and increased kidney damage, as well as Th2-type serum cytokine and autoantibody production. In contrast, only minimal changes were observed in ERalpha(-/-) mice after E-2 treatment. In a separate study, we found that in immune cells of autoimmune-prone SNF(1) and non-autoimmune DBF(1) mice, both ERalpha and ERbeta were differentially expressed and modulated by E-2. In SNF(1) mice, there were more CD4(+) and CD8(+) T cells constitutively expressing ERalpha, and the percentages of ERalpha+ dendritic cells and macrophages were increased after E-2 exposure compared to DBF(1) mice. Taken together, these observations strongly suggest a role for ERalpha in E-2-induced development of the lupus phenotype. Copyright 2009 Elsevier Inc. All rights reserved.Entities:
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Year: 2009 PMID： 19926524 DOI： 10.1016/j.clim.2009.10.004
Source DB: PubMed Journal: Clin Immunol ISSN： 1521-6616 Impact factor: 3.969