Literature DB >> 19926478

CD4 mimics targeting the mechanism of HIV entry.

Yuko Yamada1, Chihiro Ochiai, Kazuhisa Yoshimura, Tomohiro Tanaka, Nami Ohashi, Tetsuo Narumi, Wataru Nomura, Shigeyoshi Harada, Shuzo Matsushita, Hirokazu Tamamura.   

Abstract

A structure-activity relationship study was conducted of several CD4 mimicking small molecules which block the interaction between HIV-1 gp120 and CD4. These CD4 mimics induce a conformational change in gp120, exposing its co-receptor-binding site. This induces a highly synergistic interaction in the use in combination with a co-receptor CXCR4 antagonist and reveals a pronounced effect on the dynamic supramolecular mechanism of HIV-1 entry. Copyright 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 19926478     DOI： 10.1016/j.bmcl.2009.10.098

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  18 in total

1.  Enhanced exposure of human immunodeficiency virus type 1 primary isolate neutralization epitopes through binding of CD4 mimetic compounds.

Authors:  Kazuhisa Yoshimura; Shigeyoshi Harada; Junji Shibata; Makiko Hatada; Yuko Yamada; Chihiro Ochiai; Hirokazu Tamamura; Shuzo Matsushita
Journal:  J Virol       Date:  2010-05-26       Impact factor: 5.103

2.  Computational identification of novel entry inhibitor scaffolds mimicking primary receptor CD4 of HIV-1 gp120.

Authors:  Alexander M Andrianov; Ivan A Kashyn; Alexander V Tuzikov
Journal:  J Mol Model       Date:  2017-01-03       Impact factor: 1.810

3.  Design, synthesis and evaluation of small molecule CD4-mimics as entry inhibitors possessing broad spectrum anti-HIV-1 activity.

Authors:  Francesca Curreli; Dmitry S Belov; Ranjith R Ramesh; Naisargi Patel; Andrea Altieri; Alexander V Kurkin; Asim K Debnath
Journal:  Bioorg Med Chem       Date:  2016-09-24       Impact factor: 3.641

4.  Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening.

Authors:  Judith M Lalonde; Mark A Elban; Joel R Courter; Akihiro Sugawara; Takahiro Soeta; Navid Madani; Amy M Princiotto; Young Do Kwon; Peter D Kwong; Arne Schön; Ernesto Freire; Joseph Sodroski; Amos B Smith
Journal:  Bioorg Med Chem       Date:  2010-11-26       Impact factor: 3.641

5.  Computational Evaluation of HIV-1 gp120 Conformations of Soluble Trimeric gp140 Structures as Targets for de Novo Docking of First- and Second-Generation Small-Molecule CD4 Mimics.

Authors:  Francesca Moraca; Kriti Acharya; Bruno Melillo; Amos B Smith; Irwin Chaiken; Cameron F Abrams
Journal:  J Chem Inf Model       Date:  2016-09-26       Impact factor: 4.956

6.  Opening the HIV envelope: potential of CD4 mimics as multifunctional HIV entry inhibitors.

Authors:  Annemarie Laumaea; Amos B Smith; Joseph Sodroski; Andrés Finzi
Journal:  Curr Opin HIV AIDS       Date:  2020-09       Impact factor: 4.283

7.  Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV-1 Activity.

Authors:  Francesca Curreli; Young Do Kwon; Hongtao Zhang; Daniel Scacalossi; Dmitry S Belov; Artur A Tikhonov; Ivan A Andreev; Andrea Altieri; Alexander V Kurkin; Peter D Kwong; Asim K Debnath
Journal:  J Med Chem       Date:  2015-08-28       Impact factor: 7.446

8.  Binding mode characterization of NBD series CD4-mimetic HIV-1 entry inhibitors by X-ray structure and resistance study.

Authors:  Francesca Curreli; Young Do Kwon; Hongtao Zhang; Yongping Yang; Daniel Scacalossi; Peter D Kwong; Asim K Debnath
Journal:  Antimicrob Agents Chemother       Date:  2014-07-07       Impact factor: 5.191

9.  Specific Noncovalent Interactions Determine Optimal Structure of a Buried Ligand Moiety: QM/MM and Pure QM Modeling of Complexes of the Small-Molecule CD4 Mimetics and HIV-1 gp120.

Authors:  Francesca Moraca; David Rinaldo; Amos B Smith; Cameron F Abrams
Journal:  ChemMedChem       Date:  2018-02-09       Impact factor: 3.466

10.  Synthesis, Antiviral Activity, and Structure-Activity Relationship of 1,3-Benzodioxolyl Pyrrole-Based Entry Inhibitors Targeting the Phe43 Cavity in HIV-1 gp120.

Authors:  Francesca Curreli; Dmitry S Belov; Shahad Ahmed; Ranjith R Ramesh; Alexander V Kurkin; Andrea Altieri; Asim K Debnath
Journal:  ChemMedChem       Date:  2018-10-19       Impact factor: 3.466
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