E A Te Velde1, Th Veerman, V Subramaniam, Th Ruers. 1. Department of Surgical Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Abstract
AIMS AND BACKGROUND: Improved visualization of surgical targets inside of the patient helps to improve radical resection of the tumor while sparing healthy surrounding tissue. In order to achieve an image, optical contrast must be generated by properties intrinsic to the tissue, or require the attachment of special visualization labels to the tumor. In this overview the current status of the clinical use of fluorescent dyes and probes are reviewed. METHODS: In this review, all experimental and clinical studies concerning fluorescent imaging were included. In addition, in the search for the optimal fluorescent imaging modality, all characteristics of a fluorescent dye were described. FINDINGS AND CONCLUSIONS: Although the technique of imaging through fluorescence sounds promising and several animal models show efficacy, official approval of these agents for further clinical evaluation, is eagerly awaited. Copyright (c) 2009 Elsevier Ltd. All rights reserved.
AIMS AND BACKGROUND: Improved visualization of surgical targets inside of the patient helps to improve radical resection of the tumor while sparing healthy surrounding tissue. In order to achieve an image, optical contrast must be generated by properties intrinsic to the tissue, or require the attachment of special visualization labels to the tumor. In this overview the current status of the clinical use of fluorescent dyes and probes are reviewed. METHODS: In this review, all experimental and clinical studies concerning fluorescent imaging were included. In addition, in the search for the optimal fluorescent imaging modality, all characteristics of a fluorescent dye were described. FINDINGS AND CONCLUSIONS: Although the technique of imaging through fluorescence sounds promising and several animal models show efficacy, official approval of these agents for further clinical evaluation, is eagerly awaited. Copyright (c) 2009 Elsevier Ltd. All rights reserved.
Authors: Jessica A Carr; Daniel Franke; Justin R Caram; Collin F Perkinson; Mari Saif; Vasileios Askoxylakis; Meenal Datta; Dai Fukumura; Rakesh K Jain; Moungi G Bawendi; Oliver T Bruns Journal: Proc Natl Acad Sci U S A Date: 2018-04-06 Impact factor: 11.205
Authors: Loretta Scolaro; Dirk Lorenser; Wendy-Julie Madore; Rodney W Kirk; Anne S Kramer; George C Yeoh; Nicolas Godbout; David D Sampson; Caroline Boudoux; Robert A McLaughlin Journal: Biomed Opt Express Date: 2015-04-21 Impact factor: 3.732
Authors: Derrek A Heuveling; Gerard W M Visser; Mattijs de Groot; Johannes F de Boer; Marian Baclayon; Wouter H Roos; Gijs J L Wuite; C René Leemans; Remco de Bree; Guus A M S van Dongen Journal: Eur J Nucl Med Mol Imaging Date: 2012-02-17 Impact factor: 9.236
Authors: Ruth Cohen; Danielle J Vugts; Marijke Stigter-van Walsum; Gerard W M Visser; Guus A M S van Dongen Journal: Nat Protoc Date: 2013-04-25 Impact factor: 13.491