| Literature DB >> 19926144 |
Meredith A Brown1, Bariushaa Munkhtsog, Jennifer L Troyer, Steve Ross, Rani Sellers, Amanda E Fine, William F Swanson, Melody E Roelke, Stephen J O'Brien.
Abstract
Feline immunodeficiency virus (FIV), a feline lentivirus related to HIV, causes immune dysfunction in domestic and wild cats. The Pallas' cat is the only species from Asia known to harbor a species-specific strain of FIV designated FIV(Oma) in natural populations. Here, a 25% seroprevalence of FIV is reported from 28 wild Mongolian Pallas' cats sampled from 2000 to 2008. Phylogenetic analysis of proviral RT-Pol from eight FIV(Oma) isolates from Mongolia, Russia, China and Kazakhstan reveals a unique monophyletic lineage of the virus within the Pallas' cat population, most closely related to the African cheetah and leopard FIV strains. Histopathological examination of lymph node and spleen from infected and uninfected Pallas' cats suggests that FIV(Oma) causes immune depletion in its' native host. Copyright 2009 Elsevier B.V. All rights reserved.Entities:
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Year: 2009 PMID： 19926144 PMCID： PMC2822106 DOI： 10.1016/j.vetimm.2009.10.014
Source DB: PubMed Journal: Vet Immunol Immunopathol ISSN： 0165-2427 Impact factor: 2.046