OBJECTIVES: After novel findings from genomewide association studies that sequence variation on chromosome 9p21.3 is a genetic factor for coronary heart disease, we investigated whether this locus influenced the clinical and angiographic outcomes after implantation of drug-eluting stents in coronary arteries. BACKGROUND: Recently, genomewide association studies have identified a locus on chromosome 9 (approximately 100 kb in band p21.3) as the strongest genetic factor for coronary heart disease. METHODS: We studied the rs7865618, rs1537378, rs1333040, and rs1333049 polymorphisms located on chromosome 9p21.3 in a cohort of 2,028 patients who were treated with percutaneous coronary intervention and implantation of sirolimus- or paclitaxel-eluting stents. Records of 3-year adverse clinical outcomes were obtained from all stented patients. Follow-up angiography at 6 to 8 months after stenting was performed in 1,683 patients (83%). RESULTS: The polymorphisms were not significantly related with clinical outcomes at 3 years, including death (p >or= 0.18), myocardial infarction (p >or= 0.19), repeat revascularization (p >or= 0.08), and the composite end point of adverse events (death, myocardial infarction, repeat revascularization) (p >or= 0.34). No association of the polymorphisms was found with angiographic measures at follow-up, including minimal lumen diameter (p >or= 0.51), diameter stenosis (p >or= 0.31), late lumen loss (p >or= 0.05), and binary restenosis (p >or= 0.31). CONCLUSIONS: Specific polymorphisms in the chromosome 9p21.3 region that were shown to be associated with coronary heart disease in genomewide analyses were not related to the clinical and angiographic outcomes after the placement of drug-eluting stents in coronary arteries.
OBJECTIVES: After novel findings from genomewide association studies that sequence variation on chromosome 9p21.3 is a genetic factor for coronary heart disease, we investigated whether this locus influenced the clinical and angiographic outcomes after implantation of drug-eluting stents in coronary arteries. BACKGROUND: Recently, genomewide association studies have identified a locus on chromosome 9 (approximately 100 kb in band p21.3) as the strongest genetic factor for coronary heart disease. METHODS: We studied the rs7865618, rs1537378, rs1333040, and rs1333049 polymorphisms located on chromosome 9p21.3 in a cohort of 2,028 patients who were treated with percutaneous coronary intervention and implantation of sirolimus- or paclitaxel-eluting stents. Records of 3-year adverse clinical outcomes were obtained from all stented patients. Follow-up angiography at 6 to 8 months after stenting was performed in 1,683 patients (83%). RESULTS: The polymorphisms were not significantly related with clinical outcomes at 3 years, including death (p >or= 0.18), myocardial infarction (p >or= 0.19), repeat revascularization (p >or= 0.08), and the composite end point of adverse events (death, myocardial infarction, repeat revascularization) (p >or= 0.34). No association of the polymorphisms was found with angiographic measures at follow-up, including minimal lumen diameter (p >or= 0.51), diameter stenosis (p >or= 0.31), late lumen loss (p >or= 0.05), and binary restenosis (p >or= 0.31). CONCLUSIONS: Specific polymorphisms in the chromosome 9p21.3 region that were shown to be associated with coronary heart disease in genomewide analyses were not related to the clinical and angiographic outcomes after the placement of drug-eluting stents in coronary arteries.
Authors: Edward D Coverstone; Richard G Bach; LiShiun Chen; Laura J Bierut; Allie Y Li; Petra A Lenzini; Heidi C O'Neill; John A Spertus; Carmen C Sucharov; Jerry A Stitzel; Joel D Schilling; Sharon Cresci Journal: Basic Res Cardiol Date: 2018-08-10 Impact factor: 17.165
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Authors: Salim S Virani; Ariel Brautbar; Vei-Vei Lee; Elayda MacArthur; Alanna C Morrison; Megan L Grove; Vijay Nambi; Lorraine Frazier; James M Wilson; James T Willerson; Eric Boerwinkle; Christie M Ballantyne Journal: Circ J Date: 2012-02-09 Impact factor: 2.993
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Authors: Jeffrey J W Verschuren; Stella Trompet; M Lourdes Sampietro; Bastiaan T Heijmans; Werner Koch; Adnan Kastrati; Jeanine J Houwing-Duistermaat; P Eline Slagboom; Paul H A Quax; J Wouter Jukema Journal: PLoS One Date: 2013-08-09 Impact factor: 3.240
Authors: Kenneth Chan; Riyaz S Patel; Paul Newcombe; Christopher P Nelson; Atif Qasim; Stephen E Epstein; Susan Burnett; Viola L Vaccarino; A Maziar Zafari; Svati H Shah; Jeffrey L Anderson; John F Carlquist; Jaana Hartiala; Hooman Allayee; Kunihiko Hinohara; Bok-Soo Lee; Anna Erl; Katrina L Ellis; Anuj Goel; Arne S Schaefer; Nour Eddine El Mokhtari; Benjamin A Goldstein; Mark A Hlatky; Alan S Go; Gong-Qing Shen; Yan Gong; Carl Pepine; Ross C Laxton; John C Whittaker; W H Wilson Tang; Julie A Johnson; Qing K Wang; Themistocles L Assimes; Ute Nöthlings; Martin Farrall; Hugh Watkins; A Mark Richards; Vicky A Cameron; Axel Muendlein; Heinz Drexel; Werner Koch; Jeong Euy Park; Akinori Kimura; Wei-feng Shen; Iain A Simpson; Stanley L Hazen; Benjamin D Horne; Elizabeth R Hauser; Arshed A Quyyumi; Muredach P Reilly; Nilesh J Samani; Shu Ye Journal: J Am Coll Cardiol Date: 2013-01-23 Impact factor: 24.094
Authors: I-Te Lee; Mark O Goodarzi; Wen-Jane Lee; Jerome I Rotter; Yii-der Ida Chen; Kae-Woei Liang; Wen-Lieng Lee; Wayne H-H Sheu Journal: Biomed Res Int Date: 2014-04-02 Impact factor: 3.411