BACKGROUND: Th17 is a subset of T helper lymphocytes exerting inflammatory activities. Recently, it has been reported that serum IL-17 levels are high in patients with severe birch allergy. AIM OF THE STUDY: It was to compare the cytokine profile and the frequency of peripheral allergen-specific T helper producing IL-17 in patients with allergic rhinitis. METHODS: Twelve patients with persistent allergic rhinitis due to pollens and 5 healthy non-allergic subjects were evaluated during the pollen season. Th17 were evaluated by intracellular staining in T cell compartment ex-vivo and after short activation by allergens and control antigens. RESULTS: Ex-vivo PBMNC evaluation showed that allergic patients had higher frequencies of IL-17 producing T cells. Functional analysis after antigen-specific CD4+ T cell expansion demonstrated that allergic patients had higher frequencies of IL-17 producing T cells than normal subjects. CONCLUSION: This preliminary study contributes to the knowledge concerning the possible role of Th-17 cells in the response to allergens. Copyright 2009 Elsevier B.V. All rights reserved.
BACKGROUND: Th17 is a subset of T helper lymphocytes exerting inflammatory activities. Recently, it has been reported that serum IL-17 levels are high in patients with severe birch allergy. AIM OF THE STUDY: It was to compare the cytokine profile and the frequency of peripheral allergen-specific T helper producing IL-17 in patients with allergic rhinitis. METHODS: Twelve patients with persistent allergic rhinitis due to pollens and 5 healthy non-allergic subjects were evaluated during the pollen season. Th17 were evaluated by intracellular staining in T cell compartment ex-vivo and after short activation by allergens and control antigens. RESULTS: Ex-vivo PBMNC evaluation showed that allergicpatients had higher frequencies of IL-17 producing T cells. Functional analysis after antigen-specific CD4+ T cell expansion demonstrated that allergicpatients had higher frequencies of IL-17 producing T cells than normal subjects. CONCLUSION: This preliminary study contributes to the knowledge concerning the possible role of Th-17 cells in the response to allergens. Copyright 2009 Elsevier B.V. All rights reserved.
Authors: Luis Diego Archila; David Jeong; Mariona Pascal; Joan Bartra; Manel Juan; David Robinson; Mary L Farrington; William W Kwok Journal: J Allergy Clin Immunol Date: 2015-03-13 Impact factor: 10.793