Literature DB >> 19924685

Pluronic/polyethylenimine shell crosslinked nanocapsules with embedded magnetite nanocrystals for magnetically triggered delivery of siRNA.

Kyuri Lee1, Ki Hyun Bae, Yuhan Lee, Soo Hyeon Lee, Cheol-Hee Ahn, Tae Gwan Park.   

Abstract

Pluronic/polyethylenimine shell crosslinked nanocapsules with embedded magnetite nanocrystals (PPMCs) were developed for magnetically triggered delivery of siRNA. The positively charged PPMCs formed stable nanosized polyelectrolyte complexes via electrostatic interactions with negatively charged siRNA-polyethylene glycol conjugate (siRNA-s-s-PEG) that was linked via a cleavable disulfide linkage. PPMC/siRNA-s-s-PEG polyelectrolyte complexes were efficiently taken up by cancer cells upon exposure to a magnet, thereby enhancing intracellular uptake and silencing effect of siRNA. The present study suggests that these novel nanomaterials could be potentially utilized for magnetically triggered delivery of various nucleic acid-based therapeutic agents.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 19924685     DOI： 10.1002/mabi.200900291

Source DB:  PubMed          Journal:  Macromol Biosci        ISSN： 1616-5187            Impact factor:   4.979


  14 in total

Review 1.  Self-assembled and nanostructured siRNA delivery systems.

Authors:  Ji Hoon Jeong; Tae Gwan Park; Sun Hwa Kim
Journal:  Pharm Res       Date:  2011-03-18       Impact factor: 4.200

Review 2.  Polymers in small-interfering RNA delivery.

Authors:  Kaushik Singha; Ran Namgung; Won Jong Kim
Journal:  Nucleic Acid Ther       Date:  2011-06       Impact factor: 5.486

3.  Transfection of bovine fetal fibroblast with polyethylenimine (PEI) nanoparticles: effect of particle size and presence of fetal bovine serum on transgene delivery and cytotoxicity.

Authors:  D O Forcato; A E Fili; F E Alustiza; J M Lázaro Martínez; S Bongiovanni Abel; M F Olmos Nicotra; A P Alessio; N Rodríguez; C Barbero; P Bosch
Journal:  Cytotechnology       Date:  2017-03-20       Impact factor: 2.058

Review 4.  Magnetically enhanced nucleic acid delivery. Ten years of magnetofection-progress and prospects.

Authors:  Christian Plank; Olivier Zelphati; Olga Mykhaylyk
Journal:  Adv Drug Deliv Rev       Date:  2011-08-26       Impact factor: 15.470

5.  Secretion of Recombinant Human Annexin V in Fusion with the Super Folder GFP for Labelling Phosphatidylserine-Exposing Membranes.

Authors:  Aya Twair; Issam Kassem; Hossam Murad; Abdul Qader Abbady
Journal:  J Membr Biol       Date:  2021-02-19       Impact factor: 1.843

Review 6.  Research progress on siRNA delivery with nonviral carriers.

Authors:  Yan Gao; Xin-Ling Liu; Xiao-Rong Li
Journal:  Int J Nanomedicine       Date:  2011-05-11

7.  Degradable polyethylenimine derivate coupled to a bifunctional peptide R13 as a new gene-delivery vector.

Authors:  Kehai Liu; Xiaoyu Wang; Wei Fan; Qing Zhu; Jingya Yang; Jing Gao; Shen Gao
Journal:  Int J Nanomedicine       Date:  2012-02-29

8.  Degradable gene delivery systems based on Pluronics-modified low-molecular-weight polyethylenimine: preparation, characterization, intracellular trafficking, and cellular distribution.

Authors:  Wei Fan; Xin Wu; Baoyue Ding; Jing Gao; Zhen Cai; Wei Zhang; Dongfeng Yin; Xiang Wang; Quangang Zhu; Jiyong Liu; Xueying Ding; Shen Gao
Journal:  Int J Nanomedicine       Date:  2012-02-24

Review 9.  Developments in the use of nanocapsules in oncology.

Authors:  V Yurgel; T Collares; F Seixas
Journal:  Braz J Med Biol Res       Date:  2013-05-28       Impact factor: 2.590

Review 10.  Stimuli-Responsive Polymeric Nanoplatforms for Cancer Therapy.

Authors:  Di Chang; Yuanyuan Ma; Xiaoxuan Xu; Jinbing Xie; Shenghong Ju
Journal:  Front Bioeng Biotechnol       Date:  2021-06-25
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.