Literature DB >> 19924637

Nicotinamide N-Methyltransferase upregulation correlates with tumour differentiation in oral squamous cell carcinoma.

Monica Emanuelli1, Andrea Santarelli, Davide Sartini, Domenico Ciavarella, Valentina Rossi, Valentina Pozzi, Corrado Rubini, Lorenzo Lo Muzio.   

Abstract

We investigated expression levels of Nicotinamide N-Methyltransferase (NNMT), an enzyme involved in the biotransformation of many drugs and xenobiotic compounds, in oral squamous cell carcinoma (OSCC). Measurements were performed by immunohistochemistry and the relationship between tumour characteristics and NNMT levels in OSCC was studied to evaluate the effectiveness of NNMT as a prognostic marker in squamous cell carcinoma of the oral cavity. In conclusion, the present study suggests that NNMT may have potential as a biomarker and as a therapeutic target for OSCC.

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Year:  2010        PMID： 19924637     DOI： 10.14670/HH-25.15

Source DB:  PubMed          Journal:  Histol Histopathol        ISSN： 0213-3911            Impact factor:   2.303


  16 in total

1.  Overexpression of nicotinamide N-methyltransferase in HSC-2 OSCC cell line: effect on apoptosis and cell proliferation.

Authors:  Riccardo Seta; Marco Mascitti; Roberto Campagna; Davide Sartini; Stefania Fumarola; Andrea Santarelli; Michele Giuliani; Monia Cecati; Lorenzo Lo Muzio; Monica Emanuelli
Journal:  Clin Oral Investig       Date:  2018-06-07       Impact factor: 3.573

2.  N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis.

Authors:  Hui-Chang Bi; Yu-Zhuo Pan; Jing-Xin Qiu; Kristopher W Krausz; Fei Li; Caroline H Johnson; Chang-Tao Jiang; Frank J Gonzalez; Ai-Ming Yu
Journal:  Carcinogenesis       Date:  2014-08-12       Impact factor: 4.944

3.  Nicotinamide N-methyltransferase: a potential biomarker for worse prognosis in gastric carcinoma.

Authors:  Chen Chen; Xin Wang; Xing Huang; Hongmei Yong; Jiajia Shen; Qi Tang; Jin Zhu; Jian Ni; Zhenqing Feng
Journal:  Am J Cancer Res       Date:  2016-02-15       Impact factor: 6.166

4.  NNMT Silencing Activates Tumor Suppressor PP2A, Inactivates Oncogenic STKs, and Inhibits Tumor Forming Ability.

Authors:  Kamalakannan Palanichamy; Suman Kanji; Nicolaus Gordon; Krishnan Thirumoorthy; John R Jacob; Kevin T Litzenberg; Disha Patel; Arnab Chakravarti
Journal:  Clin Cancer Res       Date:  2016-11-03       Impact factor: 12.531

5.  Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases: Hypotheses and Lessons from Pellagra.

Authors:  Adrian C Williams; Lisa J Hill; David B Ramsden
Journal:  Curr Gerontol Geriatr Res       Date:  2012-03-21

6.  RNA-mediated gene silencing of nicotinamide N-methyltransferase is associated with decreased tumorigenicity in human oral carcinoma cells.

Authors:  Valentina Pozzi; Davide Sartini; Stefano Morganti; Rachela Giuliante; Giulia Di Ruscio; Andrea Santarelli; Romina Rocchetti; Corrado Rubini; Marco Tomasetti; Giovanni Giannatempo; Fiorenza Orlando; Mauro Provinciali; Lorenzo Lo Muzio; Monica Emanuelli
Journal:  PLoS One       Date:  2013-08-21       Impact factor: 3.240

7.  Nicotinamide N-methyltransferase is overexpressed in prostate cancer and correlates with prolonged progression-free and overall survival times.

Authors:  Weimin Zhou; Ming Gui; Min Zhu; Zhi Long; Lihua Huang; Jun Zhou; Leye He; Kuangbiao Zhong
Journal:  Oncol Lett       Date:  2014-06-26       Impact factor: 2.967

8.  Nicotinamide N-methyltransferase enhances resistance to 5-fluorouracil in colorectal cancer cells through inhibition of the ASK1-p38 MAPK pathway.

Authors:  Xinyou Xie; Huixing Liu; Yanzhong Wang; Yanwen Zhou; Haitao Yu; Guiling Li; Zhi Ruan; Fengying Li; Xiuhong Wang; Jun Zhang
Journal:  Oncotarget       Date:  2016-07-19

9.  Nicotinamide N‑methyltransferase induces the proliferation and invasion of squamous cell carcinoma cells.

Authors:  Young-Sool Hah; Hee Young Cho; Sun Young Jo; Young Sook Park; Eun Phil Heo; Tae-Jin Yoon
Journal:  Oncol Rep       Date:  2019-09-16       Impact factor: 3.906

10.  Nicotinamide N-methyltransferase expression in SH-SY5Y neuroblastoma and N27 mesencephalic neurones induces changes in cell morphology via ephrin-B2 and Akt signalling.

Authors:  M G Thomas; M Saldanha; R J Mistry; D T Dexter; D B Ramsden; R B Parsons
Journal:  Cell Death Dis       Date:  2013-06-13       Impact factor: 8.469
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