AIMS: Microglandular adenosis (MGA) is a rare breast lesion, which has long been considered to be hyperplastic. However, atypical forms of MGA (AMGA) and invasive carcinomas arising in the background of MGA are recorded. Recent studies have suggested that MGA may be a non-obligate precursor of invasive carcinomas that are negative for hormone receptors and lack HER-2 overexpression (triple-negative phenotype). The aim of this study was to determine whether MGA is clonal and whether it harbours chromosomal aberrations similar to those found in matched invasive ductal carcinoma of no special type (IDC-NST). METHODS AND RESULTS: We report on a case comprising MGA, AMGA and a high-grade IDC-NST. The three components were separately microdissected and subjected to genetic analysis with high-resolution microarray comparative genomic hybridisation. Identical genetic changes were detected in all components with subsequent acquisition of additional genetic aberrations in the invasive component, suggesting that MGA was the substrate for the development of the invasive carcinoma. Immunohistochemistry revealed concordant profiles across all components, characterized by triple-negative phenotype and variable positivity for basal markers. CONCLUSIONS: Similar to adenomas, MGA is, at least in some cases, a clonal lesion and may be a non-obligate precursor of a subgroup of high-grade triple-negative and basal-like breast carcinomas.
AIMS: Microglandular adenosis (MGA) is a rare breast lesion, which has long been considered to be hyperplastic. However, atypical forms of MGA (AMGA) and invasive carcinomas arising in the background of MGA are recorded. Recent studies have suggested that MGA may be a non-obligate precursor of invasive carcinomas that are negative for hormone receptors and lack HER-2 overexpression (triple-negative phenotype). The aim of this study was to determine whether MGA is clonal and whether it harbours chromosomal aberrations similar to those found in matched invasive ductal carcinoma of no special type (IDC-NST). METHODS AND RESULTS: We report on a case comprising MGA, AMGA and a high-grade IDC-NST. The three components were separately microdissected and subjected to genetic analysis with high-resolution microarray comparative genomic hybridisation. Identical genetic changes were detected in all components with subsequent acquisition of additional genetic aberrations in the invasive component, suggesting that MGA was the substrate for the development of the invasive carcinoma. Immunohistochemistry revealed concordant profiles across all components, characterized by triple-negative phenotype and variable positivity for basal markers. CONCLUSIONS: Similar to adenomas, MGA is, at least in some cases, a clonal lesion and may be a non-obligate precursor of a subgroup of high-grade triple-negative and basal-like breast carcinomas.
Authors: Elena Guerini-Rocco; Salvatore Piscuoglio; Charlotte K Y Ng; Felipe C Geyer; Maria R De Filippo; Carey A Eberle; Muzaffar Akram; Nicola Fusco; Shu Ichihara; Rita A Sakr; Yasushi Yatabe; Anne Vincent-Salomon; Emad A Rakha; Ian O Ellis; Y Hannah Wen; Britta Weigelt; Stuart J Schnitt; Jorge S Reis-Filho Journal: J Pathol Date: 2016-04 Impact factor: 7.996
Authors: Felipe C Geyer; Samuel H Berman; Caterina Marchiò; Kathleen A Burke; Elena Guerini-Rocco; Salvatore Piscuoglio; Charlotte Ky Ng; Fresia Pareja; Hannah Y Wen; Zoltan Hodi; Stuart J Schnitt; Emad A Rakha; Ian O Ellis; Larry Norton; Britta Weigelt; Jorge S Reis-Filho Journal: Mod Pathol Date: 2016-10-07 Impact factor: 7.842
Authors: Fresia Pareja; Felipe C Geyer; Caterina Marchiò; Kathleen A Burke; Britta Weigelt; Jorge S Reis-Filho Journal: NPJ Breast Cancer Date: 2016-11-16
Authors: Martin Radner; Jana Lisa van Luttikhuizen; Stephan Bartels; Janin Bublitz; Isabel Grote; Luisa Rieger; Henriette Christgen; Helge Stark; Christopher Werlein; Marcel Lafos; Doris Steinemann; Ulrich Lehmann; Matthias Christgen; Hans Kreipe Journal: J Pathol Clin Res Date: 2020-12-31