OBJECTIVES: To perform a comprehensive quantitative analysis of the existing magnetic resonance imaging (MRI) studies of the brain conducted on patients with first-episode bipolar disorder (BD). METHODS: A systematic search was performed of MRI studies that reported quantitative measurements of brain volumes of first-episode bipolar patients and healthy controls. Four meta-analyses were performed for four cerebral regions. RESULTS: Significant overall effect sizes were demonstrated, with a reduction detected in patients with BD for total intracranial and white matter volumes, but not for gray matter and whole brain volumes. CONCLUSIONS: The available MRI literature indicates that specific structural brain abnormalities are already present in first-episode bipolar patients. These do not overlap with those emerging from previous meta-analyses performed in patients with chronic BD. These findings support the hypothesis of different patterns of changes in brain morphology over the time course of bipolar disorder.
OBJECTIVES: To perform a comprehensive quantitative analysis of the existing magnetic resonance imaging (MRI) studies of the brain conducted on patients with first-episode bipolar disorder (BD). METHODS: A systematic search was performed of MRI studies that reported quantitative measurements of brain volumes of first-episode bipolarpatients and healthy controls. Four meta-analyses were performed for four cerebral regions. RESULTS: Significant overall effect sizes were demonstrated, with a reduction detected in patients with BD for total intracranial and white matter volumes, but not for gray matter and whole brain volumes. CONCLUSIONS: The available MRI literature indicates that specific structural brain abnormalities are already present in first-episode bipolarpatients. These do not overlap with those emerging from previous meta-analyses performed in patients with chronic BD. These findings support the hypothesis of different patterns of changes in brain morphology over the time course of bipolar disorder.
Authors: Patrick McGorry; Matcheri Keshavan; Sherilyn Goldstone; Paul Amminger; Kelly Allott; Michael Berk; Suzie Lavoie; Christos Pantelis; Alison Yung; Stephen Wood; Ian Hickie Journal: World Psychiatry Date: 2014-10 Impact factor: 49.548
Authors: Manpreet K Singh; Kiki D Chang; Michael C Chen; Ryan G Kelley; Amy Garrett; Myles M Mitsunaga; Layla Bararpour; Meghan Howe; Allan L Reiss; Ian H Gotlib Journal: Bipolar Disord Date: 2012-09 Impact factor: 6.744
Authors: José M Goikolea; Danai Dima; Ramón Landín-Romero; Imma Torres; Giuseppe DelVecchio; Marc Valentí; Benedikt L Amann; Caterina Mar Bonnín; Peter J McKenna; Edith Pomarol-Clotet; Sophia Frangou; Eduard Vieta Journal: Schizophr Bull Date: 2019-03-07 Impact factor: 9.306
Authors: Manpreet Sehmbi; Christopher D. Rowley; Luciano Minuzzi; Flavio Kapczinski; Jacek M. Kwiecien; Nicholas A. Bock; Benicio N. Frey Journal: J Psychiatry Neurosci Date: 2019-03-01 Impact factor: 6.186
Authors: Emma Sprooten; Jennifer Barrett; D Reese McKay; Emma E Knowles; Samuel R Mathias; Anderson M Winkler; Margaret S Brumbaugh; Stefanie Landau; Lindsay Cyr; Peter Kochunov; David C Glahn Journal: Hum Brain Mapp Date: 2016-05-16 Impact factor: 5.038