OBJECTIVE: To have a clearer understanding of the ebb and flow of depression and suicidal thinking in the early phase of psychosis, whether these events are predictable and how they relate to the early course of psychotic symptoms. METHOD: Ninety-two patients with first episode psychosis (FEP) completed measures of depression, including prodromal depression, self-harm and duration of untreated psychosis. Follow-up took place over 12 months. RESULTS: Depression occurred in 80% of patients at one or more phases of FEP; a combination of depression and suicidal thinking was present in 63%. Depression in the prodromal phase was the most significant predictor of future depression and acts of self-harm. CONCLUSION: Depression early in the emergence of a psychosis is fundamental to the development of future depression and suicidal thinking. Efforts to predict and reduce depression and deliberate self-harm in psychosis may need to target this early phase to reduce later risk.
OBJECTIVE: To have a clearer understanding of the ebb and flow of depression and suicidal thinking in the early phase of psychosis, whether these events are predictable and how they relate to the early course of psychotic symptoms. METHOD: Ninety-two patients with first episode psychosis (FEP) completed measures of depression, including prodromal depression, self-harm and duration of untreated psychosis. Follow-up took place over 12 months. RESULTS:Depression occurred in 80% of patients at one or more phases of FEP; a combination of depression and suicidal thinking was present in 63%. Depression in the prodromal phase was the most significant predictor of future depression and acts of self-harm. CONCLUSION:Depression early in the emergence of a psychosis is fundamental to the development of future depression and suicidal thinking. Efforts to predict and reduce depression and deliberate self-harm in psychosis may need to target this early phase to reduce later risk.
Authors: Rachel Upthegrove; Paris Lalousis; Pavan Mallikarjun; Katharine Chisholm; Sian Lowri Griffiths; Mariam Iqbal; Mirabel Pelton; Renate Reniers; Alexandra Stainton; Marlene Rosen; Anne Ruef; Dominic B Dwyer; Marian Surman; Theresa Haidl; Nora Penzel; Lana Kambeitz-Llankovic; Alessandro Bertolino; Paolo Brambilla; Stefan Borgwardt; Joseph Kambeitz; Rebekka Lencer; Christos Pantelis; Stephan Ruhrmann; Frauke Schultze-Lutter; Raimo K R Salokangas; Eva Meisenzahl; Stephen J Wood; Nikolaos Koutsouleris Journal: Schizophr Bull Date: 2021-01-23 Impact factor: 9.306
Authors: Dwight Dickinson; Danielle N Pratt; Evan J Giangrande; MeiLin Grunnagle; Jennifer Orel; Daniel R Weinberger; Joseph H Callicott; Karen F Berman Journal: Schizophr Bull Date: 2018-01-13 Impact factor: 9.306
Authors: Moogeh Baharnoori; Cali Bartholomeusz; Aurelie A Boucher; Lisa Buchy; Christopher Chaddock; Bonga Chiliza; Melanie Föcking; Alex Fornito; Juan A Gallego; Hiroaki Hori; Gisele Huf; Gul A Jabbar; Shi Hyun Kang; Yousri El Kissi; Jessica Merchán-Naranjo; Gemma Modinos; Nashaat A M Abdel-Fadeel; Anna-Karin Neubeck; Hsiao Piau Ng; Gabriela Novak; Olasunmbo O Owolabi; Diana P Prata; Naren P Rao; Igor Riecansky; Darryl C Smith; Renan P Souza; Renate Thienel; Hanan D Trotman; Hiroyuki Uchida; Kristen A Woodberry; Anne O'Shea; Lynn E DeLisi Journal: Schizophr Res Date: 2010-10-08 Impact factor: 4.939
Authors: Emma E M Knowles; Samuel R Mathias; Godfrey D Pearlson; Jennifer Barrett; Josephine Mollon; Dominique Denbow; Katrina Aberzik; Molly Zatony; David C Glahn Journal: Schizophr Res Date: 2018-10-26 Impact factor: 4.939
Authors: Joshua Chiappelli; Peter Kochunov; Katherine DeRiso; Kavita Thangavelu; Hemalatha Sampath; Florian Muellerklein; Katie L Nugent; Teodor T Postolache; William T Carpenter; L Elliot Hong Journal: Schizophr Res Date: 2014-08-27 Impact factor: 4.939