Literature DB >> 19922358

Chronic ethanol-induced glial fibrillary acidic protein (GFAP) immunoreactivity: an immunocytochemical observation in various regions of adult rat brain.

Hakki Dalçik1, Melda Yardimoglu, Serdar Filiz, Süheyla Gonca, Cannur Dalçik, Bekir Faruk Erden.   

Abstract

In the present study, the effects of chronic ethanol (ETOH) treatment on the glial fibrillary acidic protein (GFAP) immunoreactivity was investigated in adult rat brains. ETOH were administered as increasing concentrations of 2.4%-7.2% (v/v) gradually for 21 days. Immunocytochemistry revealed that chronic-ETOH treatment increased synthesis of GFAP. The increase in the diameter and the number of GFAP (+) cells were statistically significant compared with the control group (p <. 05). An increase of GFAP immunoreactivity was evident in various white matter and gray matter structures. We concluded that functional astrocytic cells responded to chronic ETOH exposure by increasing the synthesis of GFAP.

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Year:  2009        PMID： 19922358     DOI： 10.1080/00207450802333672

Source DB:  PubMed          Journal:  Int J Neurosci        ISSN： 0020-7454            Impact factor:   2.292


  12 in total

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Review 9.  Astroglial correlates of neuropsychiatric disease: From astrocytopathy to astrogliosis.

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