Literature DB >> 19921454

A mild and efficient synthesis of monofluorinated α-lactam pseudopeptides via a novel dehydrofluorination of Ugi products.

Nianjin Liu1, Song Cao, Jingjing Wu, Li Shen, Jinlong Yu, Jian Zhang, Hui Li, Xuhong Qian.   

Abstract

Six novel monofluorinated α-lactam pseudopeptide derivatives were synthesized via Ugi reaction using gem-difluoromethylene-containing isocyanide as a key component, followed by dehydrofluorination of Ugi products in one pot without additional base.

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Year:  2009        PMID： 19921454     DOI： 10.1007/s11030-009-9209-x

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  17 in total

1.  Molecular Recognition of Proteinminus signLigand Complexes: Applications to Drug Design.

Authors:  Robert E. Babine; Steven L. Bender
Journal:  Chem Rev       Date:  1997-08-05       Impact factor: 60.622

2.  Antimicrobial activity and protease stability of peptides containing fluorinated amino acids.

Authors:  He Meng; Krishna Kumar
Journal:  J Am Chem Soc       Date:  2007-11-28       Impact factor: 15.419

3.  Homoserine-derived cyclic sulfamidate as chiral educt for the diversity-oriented synthesis of lactam-bridged dipeptides.

Authors:  Fabrice Galaud; William D Lubell
Journal:  Biopolymers       Date:  2005       Impact factor: 2.505

4.  Development of highly potent and selective dynorphin A analogues as new medicines.

Authors:  F-D T Lung; C-H Chen; J-H Liu
Journal:  J Pept Res       Date:  2005-11

Review 5.  Management of fever in patients with cancer and treatment-induced neutropenia.

Authors:  P A Pizzo
Journal:  N Engl J Med       Date:  1993-05-06       Impact factor: 91.245

Review 6.  Concepts and progress in the development of peptide mimetics.

Authors:  G L Olson; D R Bolin; M P Bonner; M Bös; C M Cook; D C Fry; B J Graves; M Hatada; D E Hill; M Kahn
Journal:  J Med Chem       Date:  1993-10-15       Impact factor: 7.446

7.  ANTIVIRAL ACTIVITY OF 1-ADAMANTANAMINE (AMANTADINE).

Authors:  W L DAVIES; R R GRUNERT; R F HAFF; J W MCGAHEN; E M NEUMAYER; M PAULSHOCK; J C WATTS; T R WOOD; E C HERMANN; C E HOFFMANN
Journal:  Science       Date:  1964-05-15       Impact factor: 47.728

Review 8.  Peptidomimetics - antagonists of the fibrinogen receptors: molecular design, structures, properties and therapeutic applications.

Authors:  S A Andronati; T L Karaseva; A A Krysko
Journal:  Curr Med Chem       Date:  2004-05       Impact factor: 4.530

9.  Selective defluorination approach to N-Cbz-3,3-difluoro-2-difluoromethylenepyrrolidine and its application to 3,3-difluoroproline dipeptide synthesis.

Authors:  Yong Guo; Kana Fujiwara; Hideki Amii; Kenji Uneyama
Journal:  J Org Chem       Date:  2007-10-03       Impact factor: 4.354

10.  111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide analogues for melanoma imaging.

Authors:  Yubin Miao; Fabio Gallazzi; Haixun Guo; Thomas P Quinn
Journal:  Bioconjug Chem       Date:  2008-01-16       Impact factor: 4.774
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  1 in total

1.  Expanding the substrate scope of Ugi five-center, four-component reaction U-5C-4CR): ketones as coupling partners for secondary amino acids.

Authors:  Maciej Dawidowski; Sławomir Sobczak; Marcin Wilczek; Artur Kulesza; Jadwiga Turło
Journal:  Mol Divers       Date:  2013-10-24       Impact factor: 2.943
  1 in total

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