Literature DB >> 1992129

Calcium-independent phosphodiesterase inhibitors as putative antidepressants: [3-(bicycloalkyloxy)-4-methoxyphenyl]-2-imidazolidinones.

N A Saccomano1, F J Vinick, B K Koe, J A Nielsen, W M Whalen, M Meltz, D Phillips, P F Thadieo, S Jung, D S Chapin.   

Abstract

The synthesis and biological properties of a novel series of selective calcium-independent phosphodiesterase inhibitors are described. These compounds also inhibit the specific binding of [3H]rolipram to rat brain membranes and exhibit efficacy in preclinical models of antidepressant activity in mice, such as reducing immobility in the forced-swim test and reversing reserpine-induced hypothermia. Imidazolidinones 4 and 16 were found to be the most potent compounds studied.

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Year:  1991        PMID： 1992129     DOI： 10.1021/jm00105a045

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  6 in total

1.  Effects of repeated treatment with phosphodiesterase-4 inhibitors on cAMP signaling, hippocampal cell proliferation, and behavior in the forced-swim test.

Authors:  Lan Xiao; James P O'Callaghan; James M O'Donnell
Journal:  J Pharmacol Exp Ther       Date:  2011-05-12       Impact factor: 4.030

2.  Phosphodiesterase 4 in macrophages: relationship between cAMP accumulation, suppression of cAMP hydrolysis and inhibition of [3H]R-(-)-rolipram binding by selective inhibitors.

Authors:  J J Kelly; P J Barnes; M A Giembycz
Journal:  Biochem J       Date:  1996-09-01       Impact factor: 3.857

Review 3.  The role of phosphodiesterases in schizophrenia : therapeutic implications.

Authors:  Judith A Siuciak
Journal:  CNS Drugs       Date:  2008       Impact factor: 5.749

4.  Acute effects of Sceletium tortuosum (Zembrin), a dual 5-HT reuptake and PDE4 inhibitor, in the human amygdala and its connection to the hypothalamus.

Authors:  David Terburg; Supriya Syal; Lisa A Rosenberger; Sarah Heany; Nicole Phillips; Nigel Gericke; Dan J Stein; Jack van Honk
Journal:  Neuropsychopharmacology       Date:  2013-08-01       Impact factor: 7.853

5.  cAMP/PKA/CREB/GLT1 signaling involved in the antidepressant-like effects of phosphodiesterase 4D inhibitor (GEBR-7b) in rats.

Authors:  Xu Liu; Haibiao Guo; Mohammad Daud Som Sayed; Yang Lu; Ting Yang; Dongsheng Zhou; Zhongming Chen; Haitao Wang; Chuang Wang; Jiangping Xu
Journal:  Neuropsychiatr Dis Treat       Date:  2016-01-21       Impact factor: 2.570

6.  Neuroprotective Mechanisms of Three Natural Antioxidants on a Rat Model of Parkinson's Disease: A Comparative Study.

Authors:  Lyubka P Tancheva; Maria I Lazarova; Albena V Alexandrova; Stela T Dragomanova; Ferdinando Nicoletti; Elina R Tzvetanova; Yordan K Hodzhev; Reni E Kalfin; Simona A Miteva; Emanuela Mazzon; Nikolay T Tzvetkov; Atanas G Atanasov
Journal:  Antioxidants (Basel)       Date:  2020-01-06
  6 in total

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