AIMS: To describe the histopathological features of a series of patients with ketamine-related cystitis. METHODS AND RESULTS: Seventeen patients with ketamine-related cystitis, who had undergone biopsy, were identified and reviewed. Twelve showed ulceration with significant urothelial atypia. In 10 of these, immunohistochemistry was performed; 9/10 had high p53 immunoreactivity and 7/10 had moderate to high levels of Ki67 reactivity, but all were negative for cytokeratin 20. CONCLUSIONS: Ketamine can lead to reactive urothelial changes that can mimic carcinoma in situ, but the long-term cancer risk remains unknown.
AIMS: To describe the histopathological features of a series of patients with ketamine-related cystitis. METHODS AND RESULTS: Seventeen patients with ketamine-related cystitis, who had undergone biopsy, were identified and reviewed. Twelve showed ulceration with significant urothelial atypia. In 10 of these, immunohistochemistry was performed; 9/10 had high p53 immunoreactivity and 7/10 had moderate to high levels of Ki67 reactivity, but all were negative for cytokeratin 20. CONCLUSIONS:Ketamine can lead to reactive urothelial changes that can mimic carcinoma in situ, but the long-term cancer risk remains unknown.
Authors: Jason Ng; Leanna M W Lui; Joshua D Rosenblat; Kayla M Teopiz; Orly Lipsitz; Danielle S Cha; Jiaqi Xiong; Flora Nasri; Yena Lee; Kevin Kratiuk; Nelson B Rodrigues; Hartej Gill; Mehala Subramaniapillai; Rodrigo B Mansur; Roger Ho; Bing Cao; Roger S McIntyre Journal: Psychopharmacology (Berl) Date: 2021-01-23 Impact factor: 4.530
Authors: Danyon J Anderson; Jessica Zhou; David Cao; Matthew McDonald; Maya Guenther; Jamal Hasoon; Omar Viswanath; Alan D Kaye; Ivan Urits Journal: Health Psychol Res Date: 2022-09-15
Authors: Simon C Baker; Jens Stahlschmidt; Jon Oxley; Jennifer Hinley; Ian Eardley; Fiona Marsh; David Gillatt; Simon Fulford; Jennifer Southgate Journal: Acta Neuropathol Commun Date: 2013-10-08 Impact factor: 7.801