| Literature DB >> 19919138 |
Angie Garcia1, Dan Borchardt, Chia-En A Chang, Michael J Marsella.
Abstract
Thermal isomerization of CBC(an) to THC(an) [nonaromatic analogues of plant cannabinoids cannabichromene (CBC) and Delta(1)-tetrahydrocannabinol (THC), respectively] is predicted in silico and demonstrated experimentally. Density functional theory calculations support a similar isomerization mechanism for the corresponding plant cannabinoids. Docking studies suggest that THC(an), although nonaromatic, has a CB(1) receptor binding affinity similar to that of natural THC.Entities:
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Year: 2009 PMID： 19919138 DOI： 10.1021/ja907062v
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419