Literature DB >> 19917763

Method for screening compounds that influence virulence gene expression in Staphylococcus aureus.

Anita Nielsen1, Kristian F Nielsen, Dorte Frees, Thomas O Larsen, Hanne Ingmer.   

Abstract

We present a simple assay to examine effects of compounds on virulence gene expression in the human pathogen Staphylococcus aureus. The assay employs transcriptional reporter strains carrying lacZ fused to central virulence genes. Compounds affecting virulence gene expression and activity of the agr locus are scored based on color change in the presence of a chromogenic beta-galactosidase substrate. The assay can be used to screen for novel antivirulence compounds from many different sources, such as fungi, as demonstrated here.

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Year:  2009        PMID： 19917763      PMCID： PMC2798519          DOI： 10.1128/AAC.00940-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

1.  Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus.

Authors:  Ahmed Abdel-Lateff; Christine Klemke; Gabriele M König; Anthony D Wright
Journal:  J Nat Prod       Date:  2003-05       Impact factor: 4.050

Review 2.  Phenotypic taxonomy and metabolite profiling in microbial drug discovery.

Authors:  Thomas O Larsen; Jørn Smedsgaard; Kristian F Nielsen; Michael E Hansen; Jens C Frisvad
Journal:  Nat Prod Rep       Date:  2005-11-07       Impact factor: 13.423

Review 3.  Targeting virulence: a new paradigm for antimicrobial therapy.

Authors:  Anne E Clatworthy; Emily Pierson; Deborah T Hung
Journal:  Nat Chem Biol       Date:  2007-09       Impact factor: 15.040

4.  The role of environmental factors in the regulation of virulence-determinant expression in Staphylococcus aureus 8325-4.

Authors:  Pan F Chan; Simon J Foster
Journal:  Microbiology (Reading)       Date:  1998-09       Impact factor: 2.777

5.  Trichothecene production by Trichoderma brevicompactum.

Authors:  Kristian Fog Nielsen; Tom Gräfenhan; Doustmorad Zafari; Ulf Thrane
Journal:  J Agric Food Chem       Date:  2005-10-19       Impact factor: 5.279

6.  Staphylococcus aureus CcpA affects virulence determinant production and antibiotic resistance.

Authors:  Kati Seidl; Martin Stucki; Martin Ruegg; Christiane Goerke; Christiane Wolz; Llinos Harris; Brigitte Berger-Bächi; Markus Bischoff
Journal:  Antimicrob Agents Chemother       Date:  2006-04       Impact factor: 5.191

7.  Exfoliatin-producing strains define a fourth agr specificity group in Staphylococcus aureus.

Authors:  S Jarraud; G J Lyon; A M Figueiredo; G Lina; L Gérard; F Vandenesch; J Etienne; T W Muir; R P Novick
Journal:  J Bacteriol       Date:  2000-11       Impact factor: 3.490

8.  Identification of griseofulvin as an inhibitor of centrosomal clustering in a phenotype-based screen.

Authors:  Blanka Rebacz; Thomas O Larsen; Mads H Clausen; Mads H Rønnest; Harald Löffler; Anthony D Ho; Alwin Krämer
Journal:  Cancer Res       Date:  2007-07-01       Impact factor: 12.701

Review 9.  Increasing antibiotic resistance among methicillin-resistant Staphylococcus aureus strains.

Authors:  George Sakoulas; Robert C Moellering
Journal:  Clin Infect Dis       Date:  2008-06-01       Impact factor: 9.079

10.  sigmaB modulates virulence determinant expression and stress resistance: characterization of a functional rsbU strain derived from Staphylococcus aureus 8325-4.

Authors:  Malcolm J Horsburgh; Joanne L Aish; Ian J White; Les Shaw; James K Lithgow; Simon J Foster
Journal:  J Bacteriol       Date:  2002-10       Impact factor: 3.490
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  18 in total

Review 1.  Exploiting quorum sensing to confuse bacterial pathogens.

Authors:  Breah LaSarre; Michael J Federle
Journal:  Microbiol Mol Biol Rev       Date:  2013-03       Impact factor: 11.056

2.  Tools, Strains, and Strategies To Effectively Conduct Anaerobic and Aerobic Transcriptional Reporter Screens and Assays in Staphylococcus aureus.

Authors:  Erin E Price; Paulami Rudra; Javiera Norambuena; Franklin Román-Rodríguez; Jeffrey M Boyd
Journal:  Appl Environ Microbiol       Date:  2021-08-18       Impact factor: 4.792

3.  Inhibition of virulence gene expression in Staphylococcus aureus by novel depsipeptides from a marine photobacterium.

Authors:  Maria Mansson; Anita Nielsen; Louise Kjærulff; Charlotte H Gotfredsen; Matthias Wietz; Hanne Ingmer; Lone Gram; Thomas O Larsen
Journal:  Mar Drugs       Date:  2011-12-07       Impact factor: 6.085

4.  Identification of four new agr quorum sensing-interfering cyclodepsipeptides from a marine Photobacterium.

Authors:  Louise Kjaerulff; Anita Nielsen; Maria Mansson; Lone Gram; Thomas O Larsen; Hanne Ingmer; Charlotte H Gotfredsen
Journal:  Mar Drugs       Date:  2013-12-12       Impact factor: 5.118

5.  Solonamide B inhibits quorum sensing and reduces Staphylococcus aureus mediated killing of human neutrophils.

Authors:  Anita Nielsen; Maria Månsson; Martin S Bojer; Lone Gram; Thomas O Larsen; Richard P Novick; Dorte Frees; Hanne Frøkiær; Hanne Ingmer
Journal:  PLoS One       Date:  2014-01-08       Impact factor: 3.240

Review 6.  Flipping the switch: tools for detecting small molecule inhibitors of staphylococcal virulence.

Authors:  Cassandra L Quave; Alexander R Horswill
Journal:  Front Microbiol       Date:  2014-12-12       Impact factor: 5.640

7.  Cross-Talk between Staphylococcus aureus and Other Staphylococcal Species via the agr Quorum Sensing System.

Authors:  Jaime Canovas; Mara Baldry; Martin S Bojer; Paal S Andersen; Piotr K Grzeskowiak; Marc Stegger; Peter Damborg; Christian A Olsen; Hanne Ingmer
Journal:  Front Microbiol       Date:  2016-11-08       Impact factor: 5.640

8.  Nigribactin, a novel siderophore from Vibrio nigripulchritudo, modulates Staphylococcus aureus virulence gene expression.

Authors:  Anita Nielsen; Maria Mansson; Matthias Wietz; Anders N Varming; Richard K Phipps; Thomas O Larsen; Lone Gram; Hanne Ingmer
Journal:  Mar Drugs       Date:  2012-11-21       Impact factor: 5.118

9.  The post-antibiotic era: promising developments in the therapy of infectious diseases.

Authors:  Mario Zucca; Dianella Savoia
Journal:  Int J Biomed Sci       Date:  2010-06

10.  The antimicrobial lysine-peptoid hybrid LP5 inhibits DNA replication and induces the SOS response in Staphylococcus aureus.

Authors:  Sanne Gottschalk; Dan Ifrah; Sandra Lerche; Caroline T Gottlieb; Marianne T Cohn; Hiroshi Hiasa; Paul R Hansen; Lone Gram; Hanne Ingmer; Line E Thomsen
Journal:  BMC Microbiol       Date:  2013-08-14       Impact factor: 3.605
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