Literature DB >> 19917749

Interaction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium.

Xavier Henry1, Ana Amoroso, Jacques Coyette, Bernard Joris.   

Abstract

Ceftobiprole is a new cephalosporin that exhibits a high level of affinity for methicillin-resistant Staphylococcus aureus PBP 2a. It was reported that ceftobiprole did not interact with a mutated form of the low-affinity protein Enterococcus faecium PBP 5 (PBP 5fm) that, when overexpressed, confers a beta-lactam resistance phenotype to the bacterium. Our results show that ceftobiprole binds to unmutated PBP 5fm to form a stable acyl-enzyme and that ceftobiprole is able to efficiently kill a penicillin-resistant Enterococcus faecium strain that produces this protein.

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Year:  2009        PMID： 19917749      PMCID： PMC2812180          DOI： 10.1128/AAC.00983-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  In vitro evaluation of BAL9141, a novel parenteral cephalosporin active against oxacillin-resistant staphylococci.

Authors:  Ronald N Jones; Lalitagauri M Deshpande; Alan H Mutnick; Douglas J Biedenbach
Journal:  J Antimicrob Chemother       Date:  2002-12       Impact factor: 5.790

2.  Active-site and membrane topology of the DD-peptidase/penicillin-binding protein no. 6 of Enterococcus hirae (Streptococcus faecium) A.T.C.C. 9790.

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Journal:  Biochem J       Date:  1989-09-01       Impact factor: 3.857

3.  Penicillin-binding protein 5 and expression of ampicillin resistance in Enterococcus faecium.

Authors:  L B Rice; L L Carias; R Hutton-Thomas; F Sifaoui; L Gutmann; S D Rudin
Journal:  Antimicrob Agents Chemother       Date:  2001-05       Impact factor: 5.191

4.  Vancomycin for Staphylococcus aureus endocarditis in intravenous drug users.

Authors:  P M Small; H F Chambers
Journal:  Antimicrob Agents Chemother       Date:  1990-06       Impact factor: 5.191

Review 5.  Penicillin-binding proteins and the mechanism of action of beta-lactam antibiotics.

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Journal:  Annu Rev Biochem       Date:  1983       Impact factor: 23.643

Review 6.  Bacterial active-site serine penicillin-interactive proteins and domains: mechanism, structure, and evolution.

Authors:  J M Ghuysen
Journal:  Rev Infect Dis       Date:  1988 Jul-Aug

7.  In vitro and in vivo properties of Ro 63-9141, a novel broad-spectrum cephalosporin with activity against methicillin-resistant staphylococci.

Authors:  P Hebeisen; I Heinze-Krauss; P Angehrn; P Hohl; M G Page; R L Then
Journal:  Antimicrob Agents Chemother       Date:  2001-03       Impact factor: 5.191

Review 8.  The epidemiology of enterococci.

Authors:  C Chenoweth; D Schaberg
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1990-02       Impact factor: 3.267

9.  The 2.4-A crystal structure of the penicillin-resistant penicillin-binding protein PBP5fm from Enterococcus faecium in complex with benzylpenicillin.

Authors:  E Sauvage; F Kerff; E Fonzé; R Herman; B Schoot; J P Marquette; Y Taburet; D Prevost; J Dumas; G Leonard; P Stefanic; J Coyette; P Charlier
Journal:  Cell Mol Life Sci       Date:  2002-07       Impact factor: 9.261

10.  Mode of membrane insertion and sequence of a 32-amino acid peptide stretch of the penicillin-binding protein 4 of Enterococcus hirae.

Authors:  P Jacques; A el Kharroubi; J Van Beeumen; G Piras; J Coyette; J M Ghuysen
Journal:  FEMS Microbiol Lett       Date:  1991-08-01       Impact factor: 2.742
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  10 in total

1.  Efficacy of ceftobiprole Medocaril against Enterococcus faecalis in a murine urinary tract infection model.

Authors:  Kavindra V Singh; Barbara E Murray
Journal:  Antimicrob Agents Chemother       Date:  2012-03-26       Impact factor: 5.191

Review 2.  The future of the β-lactams.

Authors:  Leticia I Llarrull; Sebastian A Testero; Jed F Fisher; Shahriar Mobashery
Journal:  Curr Opin Microbiol       Date:  2010-09-29       Impact factor: 7.934

3.  Ceftaroline restores daptomycin activity against daptomycin-nonsusceptible vancomycin-resistant Enterococcus faecium.

Authors:  George Sakoulas; Warren Rose; Poochit Nonejuie; Joshua Olson; Joseph Pogliano; Romney Humphries; Victor Nizet
Journal:  Antimicrob Agents Chemother       Date:  2013-12-23       Impact factor: 5.191

4.  Activity of ceftaroline against Enterococcus faecium PBP5.

Authors:  Xavier Henry; Oliver Verlaine; Ana Amoroso; Jacques Coyette; Jean-Marie Frère; Bernard Joris
Journal:  Antimicrob Agents Chemother       Date:  2013-09-23       Impact factor: 5.191

Review 5.  One ring to rule them all: Current trends in combating bacterial resistance to the β-lactams.

Authors:  Dustin T King; Solmaz Sobhanifar; Natalie C J Strynadka
Journal:  Protein Sci       Date:  2016-03-09       Impact factor: 6.725

6.  In silico study on Penicillin derivatives and Cephalosporins for upper respiratory tract bacterial pathogens.

Authors:  K M Kumar; P Anitha; V Sivasakthi; Susmita Bag; P Lavanya; Anand Anbarasu; Sudha Ramaiah
Journal:  3 Biotech       Date:  2013-06-11       Impact factor: 2.406

Review 7.  Intrinsic and acquired resistance mechanisms in enterococcus.

Authors:  Brian L Hollenbeck; Louis B Rice
Journal:  Virulence       Date:  2012-08-15       Impact factor: 5.882

Review 8.  Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials.

Authors:  Eric Sauvage; Mohammed Terrak
Journal:  Antibiotics (Basel)       Date:  2016-02-17

Review 9.  Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).

Authors:  Massimo Sartelli; Dieter G Weber; Etienne Ruppé; Matteo Bassetti; Brian J Wright; Luca Ansaloni; Fausto Catena; Federico Coccolini; Fikri M Abu-Zidan; Raul Coimbra; Ernest E Moore; Frederick A Moore; Ronald V Maier; Jan J De Waele; Andrew W Kirkpatrick; Ewen A Griffiths; Christian Eckmann; Adrian J Brink; John E Mazuski; Addison K May; Rob G Sawyer; Dominik Mertz; Philippe Montravers; Anand Kumar; Jason A Roberts; Jean-Louis Vincent; Richard R Watkins; Warren Lowman; Brad Spellberg; Iain J Abbott; Abdulrashid Kayode Adesunkanmi; Sara Al-Dahir; Majdi N Al-Hasan; Ferdinando Agresta; Asma A Althani; Shamshul Ansari; Rashid Ansumana; Goran Augustin; Miklosh Bala; Zsolt J Balogh; Oussama Baraket; Aneel Bhangu; Marcelo A Beltrán; Michael Bernhard; Walter L Biffl; Marja A Boermeester; Stephen M Brecher; Jill R Cherry-Bukowiec; Otmar R Buyne; Miguel A Cainzos; Kelly A Cairns; Adrian Camacho-Ortiz; Sujith J Chandy; Asri Che Jusoh; Alain Chichom-Mefire; Caroline Colijn; Francesco Corcione; Yunfeng Cui; Daniel Curcio; Samir Delibegovic; Zaza Demetrashvili; Belinda De Simone; Sameer Dhingra; José J Diaz; Isidoro Di Carlo; Angel Dillip; Salomone Di Saverio; Michael P Doyle; Gereltuya Dorj; Agron Dogjani; Hervé Dupont; Soumitra R Eachempati; Mushira Abdulaziz Enani; Valery N Egiev; Mutasim M Elmangory; Paula Ferrada; Joseph R Fitchett; Gustavo P Fraga; Nathalie Guessennd; Helen Giamarellou; Wagih Ghnnam; George Gkiokas; Staphanie R Goldberg; Carlos Augusto Gomes; Harumi Gomi; Manuel Guzmán-Blanco; Mainul Haque; Sonja Hansen; Andreas Hecker; Wolfgang R Heizmann; Torsten Herzog; Adrien Montcho Hodonou; Suk-Kyung Hong; Reinhold Kafka-Ritsch; Lewis J Kaplan; Garima Kapoor; Aleksandar Karamarkovic; Martin G Kees; Jakub Kenig; Ronald Kiguba; Peter K Kim; Yoram Kluger; Vladimir Khokha; Kaoru Koike; Kenneth Y Y Kok; Victory Kong; Matthew C Knox; Kenji Inaba; Arda Isik; Katia Iskandar; Rao R Ivatury; Maurizio Labbate; Francesco M Labricciosa; Pierre-François Laterre; Rifat Latifi; Jae Gil Lee; Young Ran Lee; Marc Leone; Ari Leppaniemi; Yousheng Li; Stephen Y Liang; Tonny Loho; Marc Maegele; Sydney Malama; Hany E Marei; Ignacio Martin-Loeches; Sanjay Marwah; Amos Massele; Michael McFarlane; Renato Bessa Melo; Ionut Negoi; David P Nicolau; Carl Erik Nord; Richard Ofori-Asenso; AbdelKarim H Omari; Carlos A Ordonez; Mouaqit Ouadii; Gerson Alves Pereira Júnior; Diego Piazza; Guntars Pupelis; Timothy Miles Rawson; Miran Rems; Sandro Rizoli; Claudio Rocha; Boris Sakakushev; Miguel Sanchez-Garcia; Norio Sato; Helmut A Segovia Lohse; Gabriele Sganga; Boonying Siribumrungwong; Vishal G Shelat; Kjetil Soreide; Rodolfo Soto; Peep Talving; Jonathan V Tilsed; Jean-Francois Timsit; Gabriel Trueba; Ngo Tat Trung; Jan Ulrych; Harry van Goor; Andras Vereczkei; Ravinder S Vohra; Imtiaz Wani; Waldemar Uhl; Yonghong Xiao; Kuo-Ching Yuan; Sanoop K Zachariah; Jean-Ralph Zahar; Tanya L Zakrison; Antonio Corcione; Rita M Melotti; Claudio Viscoli; Perluigi Viale
Journal:  World J Emerg Surg       Date:  2016-07-15       Impact factor: 5.469

10.  Mechanistic Insights Into the Differential Efficacy of Daptomycin Plus β-Lactam Combinations Against Daptomycin-Resistant Enterococcus faecium.

Authors:  Razieh Kebriaei; Kyle C Stamper; Kavindra V Singh; Ayesha Khan; Seth A Rice; An Q Dinh; Truc T Tran; Barbara E Murray; Cesar A Arias; Michael J Rybak
Journal:  J Infect Dis       Date:  2020-10-01       Impact factor: 5.226
  10 in total

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