Literature DB >> 19917528

Synthesis and antitumor activity of novel 2',3'-dideoxy-2',3'-diethanethionucleosides bearing 1,2,3-triazole residues.

Jin-Lan Yu1, Qin-Pei Wu, Qing-Shan Zhang, Yan-Hong Liu, Yun-Zheng Li, Zi-Ming Zhou.   

Abstract

A series of novel 2',3'-dideoxy-2',3'-diethanethioribonucleosides and those modified with a triazole ring were prepared in excellent yields and their antitumor activity was evaluated. Nucleosides with a triazole ring, 16a-16c, showed significantly improved activity towards a broad range of tumor cell lines. Copyright 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 19917528     DOI： 10.1016/j.bmcl.2009.10.127

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Synthesis and antioxidant evaluation of enantiomerically pure bis-(1,2,3-triazolylmethyl)amino esters from modified α-amino acids.

Authors:  Juan I Sarmiento-Sánchez; Adrián Ochoa-Terán; Ignacio A Rivero
Journal:  ScientificWorldJournal       Date:  2014-10-15

Review 2.  Fluorinated triazoles as privileged potential candidates in drug development-focusing on their biological and pharmaceutical properties.

Authors:  Ihsan Ullah; Muhammad Ilyas; Muhammad Omer; Muhammad Alamzeb; Muhammad Sohail
Journal:  Front Chem       Date:  2022-08-09       Impact factor: 5.545

3.  The synthesis, antiviral, cytostatic and cytotoxic evaluation of a new series of acyclonucleotide analogues with a 1,2,3-triazole linker.

Authors:  Iwona E Głowacka; Jan Balzarini; Andrzej E Wróblewski
Journal:  Eur J Med Chem       Date:  2013-10-30       Impact factor: 6.514
  3 in total

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