Jane W Chan1, Alberto Castellanos. 1. Department of Neurology and Ophthalmology, University of Kentucky College of Medicine, KY Clinic L-445, Lexington, KY 40536, USA. worjun@aol.com
Abstract
BACKGROUND: Anti-tumor necrosis factor alpha (TNF alpha) agents have been increasingly used to treat patients with Crohn's disease, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, and persistent uveitis. We describe a 68-year-old man with Crohn's esophagitis who developed a possible bilateral toxic anterior optic neuropathy during infliximab infusion. METHODS: This is an observational case report, with review of the PubMed literature from 1977 to present. RESULTS: This 68-year-old man with a 2-year history of Crohn's esophagitis developed acute bilateral visual loss during his third infliximab infusion. His clinical features and laboratory tests were characteristic for a bilateral anterior optic neuropathy. Only three cases of possible infliximab-associated anterior optic neuropathy have been reported in the literature to date. CONCLUSION: It is important to consider the possibility of anterior optic neuropathy, in addition to retrobulbar optic neuritis, in patients who experience sudden-onset visual loss while being treated with infliximab.
BACKGROUND: Anti-tumornecrosis factor alpha (TNF alpha) agents have been increasingly used to treat patients with Crohn's disease, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, and persistent uveitis. We describe a 68-year-old man with Crohn's esophagitis who developed a possible bilateral toxic anterior optic neuropathy during infliximab infusion. METHODS: This is an observational case report, with review of the PubMed literature from 1977 to present. RESULTS: This 68-year-old man with a 2-year history of Crohn's esophagitis developed acute bilateral visual loss during his third infliximab infusion. His clinical features and laboratory tests were characteristic for a bilateral anterior optic neuropathy. Only three cases of possible infliximab-associated anterior optic neuropathy have been reported in the literature to date. CONCLUSION: It is important to consider the possibility of anterior optic neuropathy, in addition to retrobulbar optic neuritis, in patients who experience sudden-onset visual loss while being treated with infliximab.
Authors: Helio V Neves da Silva; John Placide; Anne Duong; Yasmyne Ronquillo; Shannon McCabe; Majid Moshirfar Journal: Ther Adv Ophthalmol Date: 2022-04-26
Authors: Luiz Gustavo Martins da Silva; Letícia Soares Sasso; Carlos José Nelli; Fred Bernardes Filho; Marilda Aparecida Milanez Morgado de Abreu Journal: An Bras Dermatol Date: 2013 Nov-Dec Impact factor: 1.896