Literature DB >> 19915562

Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1.

Junyu Xu1, Nan Xiao, Jun Xia.   

Abstract

In cultured rat hippocampal neurons, we found that thrombospondin 1 (TSP1) increased the speed of synapse formation in young neurons, but not the final density of synapses in mature neurons. TSP1 interacted with neuroligin 1 (NL1) and application of the NL1 extracellular domain blocked TSP1-induced synaptogenesis. Furthermore, knocking down endogenous NL1 inhibited TSP1's effect. Our results indicate that TSP1 accelerates the speed of synaptogenesis through NL1 in hippocampal neurons.

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Year:  2009        PMID： 19915562     DOI： 10.1038/nn.2459

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


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