Literature DB >> 1991506

Solution structure of mu-conotoxin GIIIA analysed by 2D-NMR and distance geometry calculations.

K H Ott1, S Becker, R D Gordon, H Rüterjans.   

Abstract

We have investigated the structure of mu-conotoxin GIIIA by 2D-NMR methods. The assignment of 1H NMR spectra and a quantitative analysis of NOE and J-coupling data are presented. These results were used for the calculation of secondary structure elements of mu-conotoxin GIIIA. Distance geometry calculations were carried out to define the global folding of the peptide.

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Year:  1991        PMID: 1991506     DOI: 10.1016/0014-5793(91)80107-e

Source DB:  PubMed          Journal:  FEBS Lett        ISSN: 0014-5793            Impact factor:   4.124


  5 in total

1.  A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors.

Authors:  Philippe Favreau; Evelyne Benoit; Henry G Hocking; Ludovic Carlier; Dieter D' hoedt; Enrico Leipold; René Markgraf; Sébastien Schlumberger; Marco A Córdova; Hubert Gaertner; Marianne Paolini-Bertrand; Oliver Hartley; Jan Tytgat; Stefan H Heinemann; Daniel Bertrand; Rolf Boelens; Reto Stöcklin; Jordi Molgó
Journal:  Br J Pharmacol       Date:  2012-07       Impact factor: 8.739

2.  Solution structure of kurtoxin: a gating modifier selective for Cav3 voltage-gated Ca(2+) channels.

Authors:  Chul Won Lee; Chanhyung Bae; Jaeho Lee; Jae Ha Ryu; Ha Hyung Kim; Toshiyuki Kohno; Kenton J Swartz; Jae Il Kim
Journal:  Biochemistry       Date:  2012-02-22       Impact factor: 3.162

3.  mu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains.

Authors:  S C Dudley; N Chang; J Hall; G Lipkind; H A Fozzard; R J French
Journal:  J Gen Physiol       Date:  2000-11       Impact factor: 4.086

4.  Molecular dynamics study of binding of µ-conotoxin GIIIA to the voltage-gated sodium channel Na(v)1.4.

Authors:  Somayeh Mahdavi; Serdar Kuyucak
Journal:  PLoS One       Date:  2014-08-18       Impact factor: 3.240

Review 5.  Mu-conotoxins as leads in the development of new analgesics.

Authors:  Raymond S Norton
Journal:  Molecules       Date:  2010-04-19       Impact factor: 4.411

  5 in total

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