Literature DB >> 19914836

Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases.

Igor Beseda1, Laszlo Czollner, Priti S Shah, Rupesh Khunt, Rawindra Gaware, Paul Kosma, Christian Stanetty, Maria Carmen Del Ruiz-Ruiz, Hassan Amer, Kurt Mereiter, Thierry Da Cunha, Alex Odermatt, Dirk Classen-Houben, Ulrich Jordis.   

Abstract

The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11beta-hydroxysteroid dehydrogenase (11beta-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29 of the GA skeleton were prepared. Single crystal X-ray diffraction data of selected substances are reported and discussed. Copyright (c) 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID: 19914836     DOI: 10.1016/j.bmc.2009.10.036

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN: 0968-0896            Impact factor:   3.641


  7 in total

1.  The licorice pentacyclic triterpenoid component 18β-glycyrrhetinic acid enhances the activity of antibiotics against strains of methicillin-resistant Staphylococcus aureus.

Authors:  A de Breij; T G Karnaoukh; J Schrumpf; P S Hiemstra; P H Nibbering; J T van Dissel; P C de Visser
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2016-01-15       Impact factor: 3.267

2.  (+)-Methyl 3β-acet-oxy-13-carb-oxy-19-hy-droxy-11-oxo-C-norolean-18-en-30-oate γ-lactone.

Authors:  Rawindra Gaware; Laszlo Czollner; Ulrich Jordis; Kurt Mereiter
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-09-18

3.  Propargylaminyl 3α-hy-droxy-11-oxo-18β-olean-12-en-29-oate.

Authors:  Laszlo Czollner; Ulrich Jordis; Kurt Mereiter
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-10-29

4.  (3β,18β,20β)-N-Eth-oxy-carbonyl-methyl-3-nitrato-11-oxoolean-12-ene-29-carboxamide methanol monosolvate.

Authors:  Laszlo Czollner; Ulrich Jordis; Kurt Mereiter
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-03-31

5.  Synthesis and antiviral activities of spacer-linked 1-thioglucuronide analogues of glycyrrhizin.

Authors:  Christian Stanetty; Andrea Wolkerstorfer; Hassan Amer; Andreas Hofinger; Ulrich Jordis; Dirk Claßen-Houben; Paul Kosma
Journal:  Beilstein J Org Chem       Date:  2012-05-08       Impact factor: 2.883

6.  Synthesis and structure-activity relationship studies of water-soluble β-cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents.

Authors:  Shuobin Liang; Man Li; Xiaojuan Yu; Hongwei Jin; Yongmin Zhang; Lihe Zhang; Demin Zhou; Sulong Xiao
Journal:  Eur J Med Chem       Date:  2019-01-30       Impact factor: 6.514

7.  Efficient synthesis of piperazinyl amides of 18β-glycyrrhetinic acid.

Authors:  Dong Cai; ZhiHua Zhang; Yufan Meng; KaiLi Zhu; LiYi Chen; ChangXiang Yu; ChangWei Yu; ZiYi Fu; DianShen Yang; YiXia Gong
Journal:  Beilstein J Org Chem       Date:  2020-04-21       Impact factor: 2.883

  7 in total

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