Literature DB >> 19914392

Transcription factor Stat5a/b as a therapeutic target protein for prostate cancer.

Zhiyong Liao1, Jacqueline Lutz, Marja T Nevalainen.   

Abstract

Prostate cancer is the most common non-cutaneous cancer in Western males. The majority of prostate cancer fatalities are caused by development of castration-resistant growth and metastatic spread of the primary tumor. The average duration of the response of primary prostate cancer to hormonal ablation is less than 3 years, and 75% of prostate cancers in the United States progress to castration-resistant disease. The existing pharmacological therapies for metastatic and/or castration-resistant prostate cancer do not provide significant survival benefit. This review summarizes the importance of transcription factor Stat5 signaling in the pathogenesis of prostate cancer and discusses the molecular basis of Stat5a/b inhibition as a therapeutic strategy for prostate cancer. Copyright (c) 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 19914392      PMCID： PMC2818495          DOI： 10.1016/j.biocel.2009.11.001

Source DB:  PubMed          Journal:  Int J Biochem Cell Biol        ISSN： 1357-2725            Impact factor:   5.085


  110 in total

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Review 8.  Getting the message across, STAT! Design principles of a molecular signaling circuit.

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Authors:  H Wakao; F Gouilleux; B Groner
Journal:  EMBO J       Date:  1994-05-01       Impact factor: 11.598
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  15 in total

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Review 4.  Signal transducer and activator of transcription 5a/b: biomarker and therapeutic target in prostate and breast cancer.

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Journal:  Int J Biochem Cell Biol       Date:  2011-06-17       Impact factor: 5.085

5.  N-terminal truncation of Stat5a/b circumvents PIAS3-mediated transcriptional inhibition of Stat5 in prostate cancer cells.

Authors:  Ayush Dagvadorj; Shyh-Han Tan; Zhiyong Liao; Jianwu Xie; Martti Nurmi; Kalle Alanen; Hallgeir Rui; Tuomas Mirtti; Marja T Nevalainen
Journal:  Int J Biochem Cell Biol       Date:  2010-09-18       Impact factor: 5.085

6.  Androgen-STAT3 activation may contribute to gender disparity in human simply renal cysts.

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7.  ING5 suppresses proliferation, apoptosis, migration and invasion, and induces autophagy and differentiation of gastric cancer cells: a good marker for carcinogenesis and subsequent progression.

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8.  The inhibition of stat5 by a Peptide aptamer ligand specific for the DNA binding domain prevents target gene transactivation and the growth of breast and prostate tumor cells.

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9.  CSF2 Overexpression Is Associated with STAT5 Phosphorylation and Poor Prognosis in Patients with Urothelial Carcinoma.

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10.  Unique protein expression signatures of survival time in kidney renal clear cell carcinoma through a pan-cancer screening.

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